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Titolo:
PHARMACOKINETICS OF INTRANASALLY-ADMINISTERED DIHYDROERGOTAMINE IN THE RAT
Autore:
LAU DTW; YU ZL; AUN RL; HASSELL AE; TSE FLS;
Indirizzi:
AMGEN INC,DEPT PHARMACOL,1840 DE HAVILLAND DR THOUSAND OAKS CA 91320 SANDOZ PHARMACEUT CORP,SANDOZ RES INST,DEPT DRUG METAB & PHARMACOKINET E HANOVER NJ 07936
Titolo Testata:
Pharmaceutical research
fascicolo: 11, volume: 11, anno: 1994,
pagine: 1530 - 1534
SICI:
0724-8741(1994)11:11<1530:POIDIT>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA;
Keywords:
DIHYDROERGOTAMINE; ERGOT ALKALOIDS; INTRANASAL DELIVERY; PHARMACOKINETICS; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
D.T.W. Lau et al., "PHARMACOKINETICS OF INTRANASALLY-ADMINISTERED DIHYDROERGOTAMINE IN THE RAT", Pharmaceutical research, 11(11), 1994, pp. 1530-1534

Abstract

Intranasal dosing of dihydroergotamine (DHE) allows convenient self-administration and provides an alternate route of administration for the treatment of migraine in addition to the existing parenteral dosage forms. In this study, the pharmacokinetics of H-3-DHE were investigated following intravenous and intranasal dosing (0.343 mg DHE/animal) inthe rat. Intranasal administration of DHE resulted in rapid absorption. The extent of absorption of the radiolabeled dose was approximately45%-60%. Absolute bioavailability of the parent drug was 35%-40%, as determined by deconvolution and by the ratios of AUC(0-infinity) following intranasal and intravenous dosing. Due to the limited capacity ofthe nostrils, approximately half of the intranasal dose was swallowedinto the gastrointestinal tract. Biliary excretion was found to be the predominant pathway of radioactivity excretion following both routesof administration. The results from this study suggest that intranasal administration provides a viable means of delivering DHE into the systemic circulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 19:19:55