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Titolo:
ANGIOTENSIN-II (AII) MODULATION OF STEROIDOGENESIS BY LUTEINIZED GRANULOSA-CELLS IN-VITRO
Autore:
MORRIS RS; FRANCIS MM; DO YS; HSUEH WA; LOBO RA; PAULSON RJ;
Indirizzi:
UNIV SO CALIF,WOMENS HOSP,SCH MED,DIV REPROD ENDOCRINOL,1240 N MISS RD,ROOM 1034 LOS ANGELES CA 90033 UNIV SO CALIF,WOMENS HOSP,SCH MED,DIV REPROD ENDOCRINOL,1240 N MISS RD,ROOM 1034 LOS ANGELES CA 90033
Titolo Testata:
Journal of assisted reproduction and genetics
fascicolo: 3, volume: 11, anno: 1994,
pagine: 117 - 122
SICI:
1058-0468(1994)11:3<117:A(MOSB>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Keywords:
OVARIAN RENIN ANGIOTENSIN SYSTEM; ANGIOTENSIN-II, SARALASIN; STEROIDOGENESIS; LUTEINIZED GRANULOSA CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
R.S. Morris et al., "ANGIOTENSIN-II (AII) MODULATION OF STEROIDOGENESIS BY LUTEINIZED GRANULOSA-CELLS IN-VITRO", Journal of assisted reproduction and genetics, 11(3), 1994, pp. 117-122

Abstract

Purpose: The purpose of the present study was to evaluate the effect of angiotensin II and its inhibitor, saralasin, on steroid production by luteinized human granulosa cells in vitro. Granulosa cells were obtained from follicular fluid aspirations from human in vitro fertilization. Cultures were established in supplemented Ham's F-10 medium. Human chorionic gonadotropin and angiotensin II were added to culture media and the effect on steroid production was measured. Results: Human chorionic gonadotropin alone stimulated production of progesterone, estradiol, and testosterone. The addition of angiotensin II resulted in a dose-dependent increase in progesterone production (428% increase compared to baseline). No effect was seen on estradiol or testosterone. However, a large increase (700%) in estradiol was seen with the additionof the competitive inhibitor of angiotensin II, saralasin. Conclusion: We conclude that angiotensin II modulates progesterone production byhuman luteinized granulosa cells in vitro. The observed enhancement of estradiol production by angiotensin blockade suggests a tonic inhibition of estradiol secretion by endogeneous angiotensin II.

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Documento generato il 20/09/20 alle ore 06:13:55