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Titolo:
ASTROCYTES BUT NOT MICROGLIA EXPRESS NADPH-DIAPHORASE ACTIVITY AFTER MOTOR-NEURON INJURY IN THE RAT
Autore:
MCELHANEY MR; CHANDLER LJ; STREIT WJ;
Indirizzi:
UNIV FLORIDA,COLL MED,DEPT NEUROSCI,POB 100244 JHMHC GAINESVILLE FL 32610 UNIV FLORIDA,COLL VET MED,DEPT COMPARAT & EXPTL PATHOL GAINESVILLE FL32610 UNIV FLORIDA,COLL MED,DEPT PHARMACOL & THERAPEUT GAINESVILLE FL 00000
Titolo Testata:
Neuroscience letters
fascicolo: 1, volume: 180, anno: 1994,
pagine: 67 - 70
SICI:
0304-3940(1994)180:1<67:ABNMEN>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; FIBRILLARY ACIDIC PROTEIN; BRAIN MACROPHAGES; GLIAL-CELLS; INDUCTION;
Keywords:
NITRIC OXIDE; GLIAL CELL; NEURODEGENERATION; AXOTOMY; ENZYME HISTOCHEMISTRY; FACIAL NUCLEUS; TOXIC RICIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
M.R. Mcelhaney et al., "ASTROCYTES BUT NOT MICROGLIA EXPRESS NADPH-DIAPHORASE ACTIVITY AFTER MOTOR-NEURON INJURY IN THE RAT", Neuroscience letters, 180(1), 1994, pp. 67-70

Abstract

The purpose of this study was to identify cellular sources of nitric oxide (NO) after injury to rat facial motor neurons using NADPH-diaphorase histochemistry. We employed intraneural injections of either saline or toxic ricin, followed by nerve crush, in order to produce regeneration or degeneration of facial motor neurons (FMNs), respectively. Reactive astrocytes responding to ricin-induced degeneration of FMNs showed increased NADPH-diaphorase activity while reactive astrocytes responding to axotomy (saline injection) did not. Reactive microglial cells were found not to express NADPH-diaphorase in either one of these two paradigms. We conclude that irreversible neuron injury resulting inneurodegeneration causes increased production of NO by reactive astrocytes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 18:11:42