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Titolo:
CLINICAL-EVALUATION OF POTENTIAL USEFULNESS OF CEA, CA-15-3, AND MCA IN FOLLOW-UP OF BREAST-CANCER PATIENTS
Autore:
JEZERSEK B; CERVEK J; RUDOLF Z; NOVAKOVIC S;
Indirizzi:
INST ONCOL,DEPT TUMOR BIOL & BIOTHERAPY LJUBLJANA SLOVENIA INST ONCOL,DEPT TUMOR BIOL & BIOTHERAPY LJUBLJANA SLOVENIA
Titolo Testata:
Cancer letters
fascicolo: 1-2, volume: 110, anno: 1996,
pagine: 137 - 144
SICI:
0304-3835(1996)110:1-2<137:COPUOC>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARCINOMA-ASSOCIATED ANTIGEN; CARCINOEMBRYONIC-ANTIGEN; TUMOR-MARKERS; DIAGNOSTIC-VALUE; MANAGEMENT; REACTIVITY; CA-15.3; CA15-3; TPA;
Keywords:
BREAST CANCER; CARCINOEMBRYONIC ANTIGEN (CEA); CANCER-ASSOCIATED ANTIGEN 15-3 (CA 15-3); MUCIN-LIKE CARCINOMA-ASSOCIATED ANTIGEN (MCA); FOLLOW-UP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
B. Jezersek et al., "CLINICAL-EVALUATION OF POTENTIAL USEFULNESS OF CEA, CA-15-3, AND MCA IN FOLLOW-UP OF BREAST-CANCER PATIENTS", Cancer letters, 110(1-2), 1996, pp. 137-144

Abstract

The potential usefulness of MCA, CA 15-3 and CEA in monitoring of breast cancer patients was evaluated in 135 female patients with histologically confirmed breast cancer. The patients were classified into two groups as follows: group of patients with no evidence of disease, NED;and group of patients with progressive disease, PD. In total, 2106 measurements of CEA, CA 15-3, and MCA were performed using an enzyme immunoassay. Serum levels of all three markers in the NED group differed significantly from those of patients with PD. The observed differencesin the sensitivity and specificity of CEA, CA 15-3, and MCA tests were not significant. The serum concentrations of a particular marker correlated well with the concentrations of the other two markers, except when CEA was correlated with MCA or CA 15-3 in NED group patients. Theelevation of tumor markers preceded by some 7 months the clinical evidence of dissemination, and marker levels reflected at a high percentage the response to therapy in PD patients. Therefore, this clinical study confirmed that MCA, CA 15-3 and also CEA are suited to discriminate between disease and disease-free periods, and also validated the usefulness of markers for treatment response monitoring.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 15:17:56