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Titolo:
E-CADHERIN EXPRESSION IN PROSTATIC-CARCINOMA BIOPSIES - CORRELATION WITH TUMOR GRADE, DNA CONTENT, PATHOLOGICAL STAGE, AND CLINICAL OUTCOME
Autore:
ROSS JS; FIGGE HL; BUI HX; DELROSARIO AD; FISHER HAG; NAZEER T; JENNINGS TA; INGLE R; KIM DN;
Indirizzi:
ALBANY MED COLL,DEPT PATHOL & LAB MED A81,47 NEW SCOTLAND AVE ALBANY NY 12208
Titolo Testata:
Modern pathology
fascicolo: 8, volume: 7, anno: 1994,
pagine: 835 - 841
SICI:
0893-3952(1994)7:8<835:EEIPB->2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULE E-CADHERIN; PROSTATECTOMY SPECIMENS; PROGNOSTIC-SIGNIFICANCE; DECREASED EXPRESSION; ADHESION MOLECULES; CANCER TISSUES; GASTRIC-CANCER; FLOW-CYTOMETRY; IMAGE-ANALYSIS; PLOIDY;
Keywords:
E-CADHERIN; PROSTATIC CARCINOMA; DNA PLOIDY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
J.S. Ross et al., "E-CADHERIN EXPRESSION IN PROSTATIC-CARCINOMA BIOPSIES - CORRELATION WITH TUMOR GRADE, DNA CONTENT, PATHOLOGICAL STAGE, AND CLINICAL OUTCOME", Modern pathology, 7(8), 1994, pp. 835-841

Abstract

We compared tumor grade and DNA content with expression of E-cadherin(E-CD), a cell adhesion molecule associated with cell-cell and cell-matrix interaction, leukocyte function, and tumor invasion and metastases, on 56 prostate carcinoma needle biopsies. The findings were correlated with final pathologic stage at subsequent prostatectomy, preoperative serum prostate-specific antigen level and further development of metastases during an initial 2.4-yr mean clinical follow-up period (range 0.5 to 5.5 yr). E-CD expression (uvomorulin, L-CAM, cell CAM 80/120, ARC-1, Sigma, St. Louis, MO) was measured by double-linked immunoalkaline phosphatase immunohistochemistry quantified with a the Roche RPW image analyzer (Roche Image Analysis Systems, Elon College, NC). DNAploidy was determined on formalin-fixed, paraffin-embedded Feulgen-stained 5-mu m tissue sections of the narrow-bore initial prostate carcinoma biopsies with the Roche RPW image analyzer. The 51% mean positivearea E-CD expression in the group of 56 adenocarcinomas was significantly less than the 76% expression level for 15 normal control prostatetissues (P < 0.001). E-CD expression was also decreased in aneuploid (39%) versus diploid tumors (54%, P < 0.001); and in high-grade (44%) versus low-grade lesions (54%; P < 0.01). The 44% E-CD expression level in patients with metastases was lower than the 52% level in the nonmetastatic cases, but this finding was not statistically significant. On multivariate logistic regression analysis, biopsy DNA ploidy status,but not tumor grade or E-CD expression level, reached independent status (P < 0.026) for the prediction of metastasis. E-CD expression did not correlate with preoperative serum prostatic-specific antigen levels. We conclude that significant loss in E-CD expression can be measured in needle biopsies of prostatic carcinoma versus normal prostate tissue; in poorly differentiated versus well-differentiated tumors; in aneuploid versus diploid specimens; and that, although not an independent predictor of outcome, E-CD expression is of significant interest andwarrants further study as a potential marker of prostate cancer development and progression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:44:10