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Titolo:
INHERITANCE OF MHC CLASS-II GENES IN IDDM STUDIED IN POPULATION-BASEDAFFECTED AND CONTROL FAMILIES
Autore:
KOCKUM I; WASSMUTH R; HOLMBERG E; MICHELSEN B; LERNMARK A;
Indirizzi:
KAROLINSKA INST,KAROLINSKA HOSP,DEPT MOLEC MED,L1-02 S-17176 STOCKHOLM SWEDEN UNIV WASHINGTON,DEPT MED,RH WILLIAMS LAB SEATTLE WA 00000 LUND UNIV,WALLENBERG LAB S-22101 LUND SWEDEN UNIV ERLANGEN NURNBERG,MED KLIN 3 ERLANGEN GERMANY UMEA UNIV,DEPT PEDIAT UMEA SWEDEN HAGEDORN RES LAB GENTOFTE DENMARK
Titolo Testata:
Diabetologia
fascicolo: 11, volume: 37, anno: 1994,
pagine: 1105 - 1112
SICI:
0012-186X(1994)37:11<1105:IOMCGI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT DIABETES-MELLITUS; NONINHERITED MATERNAL HLA; PREFERENTIAL TRANSMISSION; SEGREGATION DISTORTION; RHEUMATOID-ARTHRITIS; IDENTICAL-TWINS; ANTIGENS; SUSCEPTIBILITY; DQ; DISEASE;
Keywords:
TRANSMISSION RATES; NONINHERITED MATERNAL HAPLOTYPES; NONINHERITED PATERNAL HAPLOTYPES; HLA-DR; HLA-DQ;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
I. Kockum et al., "INHERITANCE OF MHC CLASS-II GENES IN IDDM STUDIED IN POPULATION-BASEDAFFECTED AND CONTROL FAMILIES", Diabetologia, 37(11), 1994, pp. 1105-1112

Abstract

The transmission of HLA-DR and DQ was compared between 46 families with at least one child affected by insulin dependent diabetes mellitis (IDDM) and 43 healthy control families. In the patient families, therewas an increased transmission of DR4 (p < 0.025) and DQB10302 (p < 0.01) from both parents to the index patient. There was an increased transmission of DQB10302 (p < 0.03) from the mothers only. The non-inherited maternal haplotypes showed a significantly decreased frequency (p < 0.01) of positively associated haplotypes (DR4-DQA1 0301-DQB1*0302, DR3-DQA10501-DQB1*0201) compared to all parental haplotypes in thecontrol families. In the control families neither transmission rates nor frequencies of non-inherited haplotypes differed from those expected in the control families. In conclusion, the observed reduction of IDDM-positively associated haplotypes in patient non-inherited maternalhaplotypes, but not in non-inherited paternal haplotypes, suggests that tolerance during fetal life to maternal non-inherited HLA moleculesmay be important to diabetes development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 22:25:30