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Titolo:
DOPAMINE-RECEPTOR FUNCTION IN THE BASAL GANGLIA
Autore:
GERFEN CR;
Indirizzi:
NIMH,CELL BIOL LAB,NEUROANAT SECT,BLDG 10,ROOM 2D-10 BETHESDA MD 20892
Titolo Testata:
Clinical neuropharmacology
, volume: 18, anno: 1995, supplemento:, 1
pagine: 162 - 177
SICI:
0362-5664(1995)18:<162:DFITBG>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTI-SCHIZOPHRENIC DRUGS; NIGRA PARS RETICULATA; RAT STRIATAL NEURONS; SUBSTANTIA-NIGRA; C-FOS; GLOBUS-PALLIDUS; MOTOR CONTROL; INTRACELLULAR INJECTION; OCULOMOTOR FUNCTIONS; MATRIX COMPARTMENTS;
Keywords:
PARKINSONS DISEASE; D-1- AND D-2-RECEPTOR SUBTYPES; DIRECT AND INDIRECT STRIATAL PATHWAYS; GENE REGULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
C.R. Gerfen, "DOPAMINE-RECEPTOR FUNCTION IN THE BASAL GANGLIA", Clinical neuropharmacology, 18, 1995, pp. 162-177

Abstract

Clinical disorders that affect the basal ganglia, such as Parkinson'sdisease, are believed to result from an imbalance in the activity of the two main output pathways of the striatum, the direct and indirect striatal output pathways. Dopamine (DA) modulates the activity of these pathways through the select distribution of the D-1 and D-2 DA-receptor subtypes on neurons, which give rise to the direct and indirect striatal output pathways, respectively. Studies employing quantitative in situ hybridization histochemistry have been used to analyze changes in levels of gene-regulated peptides and immediate early genes in direct and indirect striatal output neurons in response to selective D-1-and D-2-agonist treatments. D-2-receptor activation reverses and D-1-receptor activation increases gene regulation in indirect and direct striatal output neurons, respectively. These findings suggest that functional activity in the two output pathways of the striatum are oppositely regulated by DA by segregation of the D-1- and D-2-receptor subtypeson different striatal neuron populations. A proposed pharmacologic strategy for the treatment of Parkinson's disease based on these findings is suggested.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 18:42:24