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Titolo:
EPIDERMAL GROWTH-FACTOR AMELIORATES AUTOSOMAL RECESSIVE POLYCYSTIC KIDNEY-DISEASE IN MICE
Autore:
GATTONE VH; LOWDEN DA; COWLEY BD;
Indirizzi:
UNIV KANSAS,MED CTR,DEPT ANAT & CELL BIOL,3901 RAINBOW BLVD KANSAS CITY KS 66160 UNIV KANSAS,MED CTR,DEPT BIOCHEM & MOLEC BIOL KANSAS CITY KS 66160 UNIV KANSAS,MED CTR,DEPT MED KANSAS CITY KS 66160
Titolo Testata:
Developmental biology
fascicolo: 2, volume: 169, anno: 1995,
pagine: 504 - 510
SICI:
0012-1606(1995)169:2<504:EGAARP>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERUM-FREE MEDIUM; COLLECTING DUCT; SMALL-INTESTINE; FACTOR BINDING; MOUSE KIDNEY; FACTOR GENE; DIFFERENTIATION; MATURATION; EGF; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
V.H. Gattone et al., "EPIDERMAL GROWTH-FACTOR AMELIORATES AUTOSOMAL RECESSIVE POLYCYSTIC KIDNEY-DISEASE IN MICE", Developmental biology, 169(2), 1995, pp. 504-510

Abstract

C57BL/6J mice homozygous for the cpk gene exhibit an autosomal recessive (AR) form of polycystic kidney disease (PKD), similar to human ARPKD, with massive collecting duct cysts. These cysts are lined by epithelia with an immature phenotype. Since renal expression of epidermal growth factor (EGF) is also significantly decreased in affected mice, we hypothesized that renal EGF is necessary for normal developmental maturation of the collecting duct. To determine if the lack of EGF may be a decisive factor in the initiation and/or growth of collecting ductcysts, we administered exogenous EGF (1 mu g/g body wt subcutaneously) daily for Postnatal Days 3-9 (a critical period for collecting duct maturation) to C57BL/6J-cpk mice. EGF but not sham or albumin treatment retarded the development of PKD, reduced the degree of renal failureassociated with the disease, and prolonged the survival of cystic mice. Sulfated glycoprotein-2 gene expression, a marker of immaturity in collecting duct cells, was reduced in cystic kidney by EGF treatment. This finding indicates that EGF treatment was associated with an increase in the maturation of the collecting duct epithelial cells. These findings support the view that decreased EGF may play a significant role in promoting the enlargement of collecting duct cysts in a hereditary model of ARPKD and that PKD involves defective and/or arrested collecting duct cell maturation. (C) 1995 Academic Press,Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 03:14:39