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Titolo:
POSSIBLE ASSOCIATION BETWEEN THE DOPAMINE D-3 RECEPTOR GENE AND BIPOLAR AFFECTIVE-DISORDER
Autore:
PARSIAN A; CHAKRAVERTY S; TODD RD;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT PSYCHIAT,4940 CHILDRENS PL ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT GENET ST LOUIS MO 63110
Titolo Testata:
American journal of medical genetics
fascicolo: 3, volume: 60, anno: 1995,
pagine: 234 - 237
SICI:
0148-7299(1995)60:3<234:PABTDD>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
NO ASSOCIATION; SCHIZOPHRENIA; HOMOZYGOSITY; ALLELES; D3;
Keywords:
BIPOLAR AFFECTIVE DISORDER; DOPAMINE D-3 RECEPTOR GENE; HAPLOTYPE RELATIVE RISK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
A. Parsian et al., "POSSIBLE ASSOCIATION BETWEEN THE DOPAMINE D-3 RECEPTOR GENE AND BIPOLAR AFFECTIVE-DISORDER", American journal of medical genetics, 60(3), 1995, pp. 234-237

Abstract

A variety of studies have reported possible genetic associations between bipolar affective disorder and different loci using relative risk (case-control) comparisons, An alternative approach is to construct a contrast group using parental alleles which were not transmitted to anaffected individual [Falk and Rubinstein, 1987: Ann Hum Genet 51:227-233], We have used both approaches to test for possible associations between alleles of the dopamine D-3 receptor gene and bipolar affectivedisorder, For relative risk studies, the probands of multiple incidence bipolar affective disorder families have been compared to alcoholicand psychiatrically normal contrast groups, Non-transmitted allele approaches have used bipolar affective disorder and alcoholic probands in which both parents were available for genotyping, Using the BalI restriction enzyme site polymorphism of Lannfelt et al. [1992: Psychiatr Genet 2:249-256], we have found no differences in the allele or genotype frequencies for bipolar vs, alcoholic or psychiatrically normal controls, In contrast, we have found evidence for an increased frequency of allele 1 and allele 1 containing genotypes in transmitted alleles from bipolar families. (C) 1995 Wiley-Liss, Inc.

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Documento generato il 14/07/20 alle ore 10:17:46