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Titolo:
THERMAL-DEGRADATION OF CLOZAPINE-N-OXIDE TO CLOZAPINE DURING GAS-CHROMATOGRAPHIC ANALYSIS
Autore:
MARKOWITZ JS; PATRICK KS;
Indirizzi:
MED UNIV S CAROLINA,DEPT PHARMACEUT SCI,171 ASHLEY AVE CHARLESTON SC 29425 MED UNIV S CAROLINA,DEPT PHARMACEUT SCI CHARLESTON SC 29425 MED UNIV S CAROLINA,DEPT HOSP PHARM PRACTICE & ADM CHARLESTON SC 29425
Titolo Testata:
Journal of chromatography B. Biomedical applications
fascicolo: 1, volume: 668, anno: 1995,
pagine: 171 - 174
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIQUID-CHROMATOGRAPHY; NORCLOZAPINE; METABOLISM; SERUM;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
J.S. Markowitz e K.S. Patrick, "THERMAL-DEGRADATION OF CLOZAPINE-N-OXIDE TO CLOZAPINE DURING GAS-CHROMATOGRAPHIC ANALYSIS", Journal of chromatography B. Biomedical applications, 668(1), 1995, pp. 171-174

Abstract

Studies were undertaken to determine if clozapine-N-oxide, the principal urinary metabolite of the antipsychotic agent clozapine, may interfere with the gas chromatographic-mass spectrometric bioanalysis of clozapine. Following injection of clozapine-N-oxide onto a (5% phenyl)methylpolysiloxane capillary column operated at 250 degrees C, significant on-column reduction of clozapine-N-oxide to the parent drug occurred. Accordingly, preparation of biological samples for clozapine determination by gas chromatography should avoid conditions which reportedlyco-extract the N-oxide to assure no artifactual contribution of this metabolite in the detection of clozapine.

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Documento generato il 21/01/20 alle ore 00:57:05