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Titolo:
DISTRIBUTION OF LIPIDS IN 8,500 MEN WITH CORONARY-ARTERY DISEASE
Autore:
RUBINS HB; ROBINS SJ; COLLINS D; IRANMANESH A; WILT TJ; MANN D; MAYOSMITH M; FAAS FH; ELAM MB; RUTAN GH; ANDERSON JW; KASHYAP ML; SCHECTMAN G;
Indirizzi:
VET AFFAIRS MED CTR,GEN INTERNAL MED SECT 1110 MINNEAPOLIS MN 55417 VET AFFAIRS MED CTR,DEPT MED MINNEAPOLIS MN 55417 UNIV MINNESOTA,SCH MED MINNEAPOLIS MN 55455 VET ADM MED CTR,DEPT MED BOSTON MA 00000 VET ADM MED CTR,LIPID METAB SECT BOSTON MA 00000 BOSTON UNIV,SCH MED BOSTON MA 02118 VET ADM MED CTR,CTR VET AFFAIRS COOPERAT STUDIES COORDINATING W HAVENCT 06516
Titolo Testata:
The American journal of cardiology
fascicolo: 17, volume: 75, anno: 1995,
pagine: 1196 - 1201
SICI:
0002-9149(1995)75:17<1196:DOLI8M>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
DENSITY-LIPOPROTEIN CHOLESTEROL; SECONDARY PREVENTION TRIAL; UNITED-STATES ADULTS; MYOCARDIAL-INFARCTION; HEART-DISEASE; SERUM-CHOLESTEROL; PLASMA; RISK; PREVALENCE; RATIONALE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
H.B. Rubins et al., "DISTRIBUTION OF LIPIDS IN 8,500 MEN WITH CORONARY-ARTERY DISEASE", The American journal of cardiology, 75(17), 1995, pp. 1196-1201

Abstract

In the present study we measured fasting lipid profiles in over 8,500community-living men with coronary artery disease (CAD) to determine the distribution of lipid abnormalities in this population: 81% were white and 16% black,; mean age 62.9 +/- 8 years; mean total cholesterol214 +/- 41 mg/dl; low-density lipoprotein (LDL) cholesterol 140 +/- 37 mg/dl; high-density lipoprotein (HDL) cholesterol 39 +/- 11 mg/dl; and triglycerides 190 +/- 142 mg/dl. After adjusting for age, the only significant difference between blacks and whites was a higher HDL cholesterol in blacks (45 vs 38 mg/dl, p <0.003). With use of cut points established by the National Cholesterol Education Program, 87% of subjects had high LDL cholesterol (greater than or equal to 100 mg/dl), 38%had HDL cholesterol (<35 mg/dl), and 33% had high triglycerides (>200mg/dl). We estimated that 42% of men with CAD would be definite candidates for cholesterol-lowering medication according to the National Cholesterol Education Program guidelines and that 41% of those in whom cholesterol-lowering medication would not be definitely indicated had low levels of HDL cholesterol. We conclude that (1) black men with CAD have substantially higher HDL cholesterol than white men, (2) almost 90% of male patients with CAD are candidates for dietary intervention and >40% may need medications to lower LDL cholesterol, and (3) 40% of patients without a definite indication for cholesterol-lowering medications have low levels of HDL cholesterol.

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Documento generato il 02/12/20 alle ore 15:25:28