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Titolo:
CRITICAL ISSUES IN PERIODONTAL RESEARCH
Autore:
PAGE RC;
Indirizzi:
UNIV WASHINGTON,REG CLIN DENT RES CTR,DEPT PERIODONT SEATTLE WA 98195 UNIV WASHINGTON,REG CLIN DENT RES CTR,DEPT PATHOL SEATTLE WA 98195 UNIV WASHINGTON,SCH MED,ORAL BIOL RES CTR SEATTLE WA 98195 UNIV WASHINGTON,HLTH SCI CTR,SCH DENT SEATTLE WA 98195
Titolo Testata:
Journal of dental research
fascicolo: 4, volume: 74, anno: 1995,
pagine: 1118 - 1128
SICI:
0022-0345(1995)74:4<1118:CIIPR>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAPIDLY PROGRESSIVE PERIODONTITIS; BACTEROIDES-GINGIVALIS W50; NON-SURGICAL TREATMENT; ACTINOBACILLUS-ACTINOMYCETEMCOMITANS; PORPHYROMONAS-GINGIVALIS; ATTACHMENT LOSS; INFLAMMATORY MEDIATORS; JUVENILE PERIODONTITIS; SUBGINGIVAL PLAQUE; BACTERIAL-ANTIGENS;
Keywords:
PERIODONTITIS; THERAPY; DIAGNOSTIC TESTS; INFLAMMATION; EPIDEMIOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
96
Recensione:
Indirizzi per estratti:
Citazione:
R.C. Page, "CRITICAL ISSUES IN PERIODONTAL RESEARCH", Journal of dental research, 74(4), 1995, pp. 1118-1128

Abstract

The purpose of this paper is to highlight briefly the major achievements and the remaining critical issues in the areas of epidemiology, microbiology, pathogenesis, diagnosis, and therapy. Periodontitis affects a relatively small proportion of study populations in the United States and other countries. Prevalence may be decreasing, but that remains to be seen. The identity and characteristics of susceptible individuals and groups are not known, and risk indicators for severe disease are only beginning to be identified. A very large number of different microbial species has been implicated in the etiology. It seems unlikely that all of these are essential participants. Essential participantsneed to be identified and better characterized. Whether putative pathogens are members of the commensal flora or exogenous species that must be transmitted is unclear. The relationship between the presence of a pathogenic flora and disease status is obscure. Pathogenic bacterialspecies are essential, but insufficient to cause disease. A susceptible host and local environmental factors-for example, elevated iron concentration-may be necessary for disease to occur. Many clonal types may not be virulent, and numbers greater than certain threshold levels appear to be necessary. The pathways by which bone and connective tissues of the periodontium are destroyed are sufficiently understood to permit development of therapies aimed at their modification. Examples are the use of vaccines, topical application of anti-inflammatory drugs,and use of chemically modified tetracyclines.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 15:55:43