Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
L-ARGININE DEPLETION BY ARGINASE REDUCES NITRIC-OXIDE PRODUCTION IN ENDOTOXIC-SHOCK - AN ELECTRON-PARAMAGNETIC-RESONANCE STUDY
Autore:
BUNE AJ; SHERGILL JK; CAMMACK R; COOK HT;
Indirizzi:
UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED,ST MARYS HOSP,SCH MED,DEPT HISTOPATHOL,NORFOLK PL LONDON W2 1PG ENGLAND UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED,ST MARYS HOSP,SCH MED,DEPT HISTOPATHOL LONDON W2 1PG ENGLAND UNIV LONDON KINGS COLL,DIV LIFE SCI,CTR STUDY MET BIOL & MED LONDON W8 7AH ENGLAND
Titolo Testata:
FEBS letters
fascicolo: 2-3, volume: 366, anno: 1995,
pagine: 127 - 130
SICI:
0014-5793(1995)366:2-3<127:LDBARN>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
TARGET-CELLS; EFFECTOR; MACROPHAGES; INHIBITION; INDUCTION; SYNTHASE; TUMOR; RAT;
Keywords:
NITRIC OXIDE; ARGINASE; LIPOPOLYSACCHARIDE; ENDOTOXIC SHOCK; ARGININE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
A.J. Bune et al., "L-ARGININE DEPLETION BY ARGINASE REDUCES NITRIC-OXIDE PRODUCTION IN ENDOTOXIC-SHOCK - AN ELECTRON-PARAMAGNETIC-RESONANCE STUDY", FEBS letters, 366(2-3), 1995, pp. 127-130

Abstract

Nitric oxide (NO) synthesis was measured in the liver, lung, spleen and kidney of lipopolysaccharide-treated male rats using the nitric oxide spin trap, iron (II)-diethyldithiocarbamate (FeDETC(2)). Nitric oxide formation in vivo was determined by the increase in intensity of the characteristic tripler hyperfine EPR spectrum of [NO-FeDETC(2)]. Intravenous bovine liver arginase, at a dose which completely depleted circulating arginine, significantly reduced the formation of nitric oxide in these tissues. The general decrease in NO levels was confirmed bythe decrease in plasma nitrite levels. These results directly demonstrate that NO formation in endotoxic shock depends on extracellular arginine; depletion of plasma arginine may be a useful therapeutic strategy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 19:39:46