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Titolo:
AT THE CUTTING EDGE - PESTICIDES - MULTIPLE MECHANISMS OF DEMASCULINIZATION
Autore:
LEBLANC GA; BAIN LJ; WILSON VS;
Indirizzi:
N CAROLINA STATE UNIV,DEPT TOXICOL,BOX 7633 RALEIGH NC 27695
Titolo Testata:
Molecular and cellular endocrinology
fascicolo: 1, volume: 126, anno: 1997,
pagine: 1 - 5
SICI:
0303-7207(1997)126:1<1:ATCE-P>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEVELOPMENTAL TOXICITY; THYROID-HORMONE; BREAST-CANCER; SEXUAL-DIFFERENTIATION; REPRODUCTIVE TOXICITY; GROWTH-HORMONE; RAT-LIVER; EXPRESSION; KETOCONAZOLE; EXPOSURE;
Keywords:
PESTICIDES; DEMASCULINIZATION; FEMINIZATION; ENDOCRINE; STEROID HORMONES; RECEPTORS; BIOTRANSFORMATION; SYNERGISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
71
Recensione:
Indirizzi per estratti:
Citazione:
G.A. Leblanc et al., "AT THE CUTTING EDGE - PESTICIDES - MULTIPLE MECHANISMS OF DEMASCULINIZATION", Molecular and cellular endocrinology, 126(1), 1997, pp. 1-5

Abstract

Many pesticides are known to produce reproductive and developmental effects in chronically-exposed non-target organisms, including humans. Recent evidence suggests that demasculinization may be an important mechanism responsible for some of these effects. Some pesticides have been shown to interact with the androgen receptor and to act as antagonists, while others have been shown to interact with the estrogen receptor and function as estrogens both in vitro and in vivo. Many pesticides can also lower serum androgen levels by altering rates of synthesis or metabolism. Given the ubiquity of pesticides in the environment andthe multiple mechanisms whereby they can elicit demasculinizing effects, synergy between such compounds may produce clinical endocrine dysfunction at current human exposure levels. Copyright (C) 1997 Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 21:49:35