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Titolo:
INVOLVEMENT OF SEPTIDE-SENSITIVE TACHYKININ RECEPTORS IN INOSITOL PHOSPHOLIPID HYDROLYSIS IN THE RAT URINARY-BLADDER
Autore:
TORRENS Y; BEAUJOUAN JC; SAFFROY M; GLOWINSKI J;
Indirizzi:
COLL FRANCE,INSERM,U114,CHAIRE NEUROPHARMACOL,11 PL MARCELIN BERTHELOT F-75231 PARIS 05 FRANCE
Titolo Testata:
Peptides
fascicolo: 4, volume: 16, anno: 1995,
pagine: 587 - 594
SICI:
0196-9781(1995)16:4<587:IOSTRI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIG ILEUM; SUBSTANCE-P RECEPTOR; SELECTIVE AGONISTS; BINDING-SITES; CORTICAL ASTROCYTES; PERIPHERAL-TISSUES; ANTAGONISTS; BIOASSAY; RP-67580; HAMSTER;
Keywords:
TACHYKININS; SEPTIDE; INOSITOL PHOSPHOLIPID HYDROLYSIS; RAT URINARY BLADDER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
Y. Torrens et al., "INVOLVEMENT OF SEPTIDE-SENSITIVE TACHYKININ RECEPTORS IN INOSITOL PHOSPHOLIPID HYDROLYSIS IN THE RAT URINARY-BLADDER", Peptides, 16(4), 1995, pp. 587-594

Abstract

The selective NK? agonist [Lys(5),MeLeu(9),Nle(10)]NKA(4-10) markedlystimulated [H-3]inositol monophosphate (IPI) formation in prisms fromthe rat urinary bladder. This response was blocked by the NK, antagonist SR 48968. Senktide (NK, agonist) was inactive. Septide, a short SPanalogue, and the NK1 agonists [Pro(9)]SP and [Sar(9)]Met(O-2)(11)]SPalso stimulated [H-3]IP1 formation and several NKI tachykinin antagonists (RP 67580, CP 96345, GR 82334, and [D-Pro(9), t beta-BPr10,Trp(11)]SP) were more potent in blocking the septide than the [Pro(9)]SP response. GR 82334 was the most discriminative. SR 48968 (10(-6) M) shifted the [Pro(9)]SP dose-response curve but did not modify the septide dose-response curve. Septide had a low affinity for [H-3][Pro(9)]SP binding sites, suggesting further that septide and NKI agonists act on different receptors. Finally, both [Pro(9)]SP and [Sar(9),Met(O-2)(11)]SP blocked the septide-evoked response, acting as partial agonists at the septide-sensitive tachykinin receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/06/20 alle ore 09:35:47