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Titolo:
THE INFLUENCE OF LEUKOCYTE FILTRATION DURING CARDIOPULMONARY BYPASS ON POSTOPERATIVE LUNG-FUNCTION - A CLINICAL-STUDY
Autore:
MIHALJEVIC T; TONZ M; VONSEGESSER LK; PASIC M; GROB P; FEHR J; SEIFERT B; TURINA M;
Indirizzi:
UNIV ZURICH HOSP,CARDIOVASC SURG CLIN,RAEMISTR 100 CH-8091 ZURICH SWITZERLAND UNIV ZURICH HOSP,DEPT CLIN IMMUNOL CH-8091 ZURICH SWITZERLAND UNIV ZURICH HOSP,DEPT HEMATOL CH-8091 ZURICH SWITZERLAND UNIV ZURICH,DEPT BIOSTAT ISPM ZURICH SWITZERLAND
Titolo Testata:
Journal of thoracic and cardiovascular surgery
fascicolo: 6, volume: 109, anno: 1995,
pagine: 1138 - 1145
SICI:
0022-5223(1995)109:6<1138:TIOLFD>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPLEMENT ACTIVATION; NEUTROPHIL ELASTASE; GENERATION; DEPLETION; INJURY; PEROXIDATION; OPERATIONS; RESPONSES; PRODUCTS; RELEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
T. Mihaljevic et al., "THE INFLUENCE OF LEUKOCYTE FILTRATION DURING CARDIOPULMONARY BYPASS ON POSTOPERATIVE LUNG-FUNCTION - A CLINICAL-STUDY", Journal of thoracic and cardiovascular surgery, 109(6), 1995, pp. 1138-1145

Abstract

The accumulation of activated leukocytes in the pulmonary circulationplays an important role in the pathogenesis of lung dysfunction associated with cardiopulmonary bypass, Animal studies have demonstrated that the elimination of leukocytes from the circulation reduces postoperative lung injury and improves postoperative pulmonary function, We conducted a prospective randomized clinical study to evaluate whether postoperative lung function could be improved by use of a leukocyte filter during cardiopulmonary bypass, Elective coronary artery bypass grafting was done with a leukocyte-depleting arterial blood filter incorporated in the extracorporeal circuit (14 patients, leukocyte filter group) or without the filter (18 patients, control group), Blood samples collected at intervals before, during, and after operation were used for analysis of blood cell counts, elastase concentrations, and arterial blood gases, The use of the leukocyte filter caused no significant reduction in leukocyte count (p = 0.86), There were no differences in postoperative lung function between the groups, as assessed through (1)oxygenation index (290 for leukocyte filter group compared with 329 for control group, 95% confidence interval, 286 to 372, p = 0.21), (2) pulmonary vascular resistance (p = 0.10), and (3) intubation time (16.6 hours for leukocyte filter group versus 15.7 hours for control group, 95% confidence interval, 12.1 to 19.1 hours, p = 0.72), The levels of neutrophil elastase were significantly higher at the end of cardiopulmonary bypass in the leukocyte filter group (460 mu g/L in leukocyte filter group versus 230 mu g/L in control group, 95% confidence interval, 101 to 359 mu g/L, p = 0.003), We conclude that the clinical use of the present form of leukocyte-depleting filter did not improve any of the postoperative lung function parameters analyzed in this study.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 19:09:10