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Titolo:
THROMBOMODULIN INHIBITS INTRAHEPATIC SPREAD IN HUMAN HEPATOCELLULAR-CARCINOMA
Autore:
SUEHIRO T; SHIMADA M; MATSUMATA T; TAKETOMI A; YAMAMOTO K; SUGIMACHI K;
Indirizzi:
KYUSHU UNIV,FAC MED,DEPT SURG 2,HIGASHI KU,3-1-1 MAIDASHI FUKUOKA 812JAPAN
Titolo Testata:
Hepatology
fascicolo: 5, volume: 21, anno: 1995,
pagine: 1285 - 1290
SICI:
0270-9139(1995)21:5<1285:TIISIH>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMINOGEN-ACTIVATOR PRODUCTION; PROTEIN-C; TUMOR-CELL; BLOOD-COAGULATION; MONOCLONAL-ANTIBODIES; METASTASIS INVIVO; CANCER CELLS; FACTOR-VIII; FACTOR-V; THROMBIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
T. Suehiro et al., "THROMBOMODULIN INHIBITS INTRAHEPATIC SPREAD IN HUMAN HEPATOCELLULAR-CARCINOMA", Hepatology, 21(5), 1995, pp. 1285-1290

Abstract

Thrombomodulin (TM) converts thrombin from procoagulant into anticoagulant protein to activate protein C. Thrombin also plays an important role in the metastatic process of cancer cells. We performed an immunohistochemical and clinicopathological study of TM in 141 cases with resected hepatocellular carcinoma (HCC) measuring less than 6 cm in diameter. Twenty-five specimens (17.73%) stained positive for TM. TM was found in the cytoplasm and surface of cancer cells. The clinicopathological findings according to the positive of TM are examined in HCC. Thepreoperative plasma TM level of the patients with tissue that stainedpositive for TM was significantly higher than that of the patients with negative results; for the postoperative TM level, there were no differences between them, In addition, the frequencies of intrahepatic metastasis, tumor thrombus in the portal vein, and capsular infiltrationwere significantly lower in patients whose tissue stained positive for TM ban in patients whose tissue stained negative for TM. The recurrence freedom rate was significantly higher in patients whose tissue stained positive for TM than patients whose tissue stained negative for TM. Thus, TM-producing HCC shows a slow intrahepatic spread. Therefore,these findings suggest that TM may inhibit the adhesion of tumor cells to the portal vein because of anticoagulant activity and thus prevent the spread of intrahepatic metastasis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:47:08