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Titolo:
MAGNETIC-RESONANCE SPECTROSCOPY IN CHILDHOOD AIDS ENCEPHALOPATHY
Autore:
PAVLAKIS SG; LU DF; FRANK Y; BAKSHI S; PAHWA S; BARNETT TA; PORRICOLO ME; GOULD RJ; NOZYCE ML; HYMAN RA;
Indirizzi:
NEW YORK HOSP,MED CTR,525 E 68TH ST,BOX 91 NEW YORK NY 10021 N SHORE UNIV HOSP,DEPT RADIOL MANHASSET NY 00000 N SHORE UNIV HOSP,DEPT PEDIAT MANHASSET NY 00000 N SHORE UNIV HOSP,DEPT NEUROL MANHASSET NY 00000 CORNELL UNIV,COLL MED NEW YORK NY 00000 BRONX LEBANON HOSP CTR,DEPT PEDIAT BRONX NY 00000
Titolo Testata:
Pediatric neurology
fascicolo: 4, volume: 12, anno: 1995,
pagine: 277 - 282
SICI:
0887-8994(1995)12:4<277:MSICAE>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; HIV-INFECTION; DEMENTIA COMPLEX; PROGRESSIVE ENCEPHALOPATHY; CEREBROSPINAL-FLUID; EVOKED-POTENTIALS; NEURONAL LOSS; CHILDREN; BRAIN; EEG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
S.G. Pavlakis et al., "MAGNETIC-RESONANCE SPECTROSCOPY IN CHILDHOOD AIDS ENCEPHALOPATHY", Pediatric neurology, 12(4), 1995, pp. 277-282

Abstract

Twenty-five children with acquired immunodeficiency syndrome (AIDS) underwent cranial magnetic resonance imaging and proton magnetic resonance spectroscopy. Patients were divided into 2 groups based on clinical parameters: encephalopathy and nonencephalopathy. N-acetyl aspartate/creatine ratios were compared between the 2 groups and to control data. Spectra were obtained for 2 volumes of interest: the basal ganglia region and the white matter. The mean basal ganglia region ratio for the AIDS encephalopathy patients (n = 8) was 1.12 and the ratio for theAIDS nonencephalopathy patients (n = 17) was 1.48. The ratio for the 9 controls was 1.57. The encephalopathy group had a significantly lower ratio than both the control (P < .001) and the AIDS nonencephalopathy group (P < .002). The mean white matter ratio for the encephalopathygroup (n = 8) was 1.47 and for the AIDS nonencephalopathy group (n = 13) was 1.82 with a control (n = 6) ratio of 1.82. The encephalopathy patients had a lower white matter ratio than the nonencephalopathy (P < .05) patients but the ratio was not different than controls (P < .11). It is concluded that N-acetyl aspartate/creatine ratios are reducedin childhood AIDS encephalopathy and proton magnetic resonance spectroscopy may be helpful in defining brain human immunodeficiency virus-1infection. However, further longitudinal studies are necessary to determine the sensitivity and specificity of this technique.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 10:04:03