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Titolo:
INCREASE OF CL- SECRETION INDUCED BY KAMPO MEDICINE (JAPANESE HERBAL MEDICINE), SAI-REI-TO, IN MONGOLIAN GERBIL MIDDLE-EAR EPITHELIUM
Autore:
IKEDA K; FURUKAWA M; TANNO N; YAMAYA M; TAKASAKA T;
Indirizzi:
TOHOKU UNIV,SCH MED,DEPT OTORHINOLARYNGOL SENDAI MIYAGI 98077 JAPAN TOHOKU UNIV,SCH MED,DEPT GERIATR MED SENDAI MIYAGI 98077 JAPAN
Titolo Testata:
Japanese Journal of Pharmacology
fascicolo: 1, volume: 73, anno: 1997,
pagine: 29 - 32
SICI:
0021-5198(1997)73:1<29:IOCSIB>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
OTITIS-MEDIA; MUCOCILIARY FUNCTION; EFFUSION; TRANSPORT; CELL;
Keywords:
SHORT-CIRCUIT CURRENT; CL- SECRETION; BASAL SECRETION; OTITIS MEDIA WITH EFFUSION; MUCOCILIARY TRANSPORT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
K. Ikeda et al., "INCREASE OF CL- SECRETION INDUCED BY KAMPO MEDICINE (JAPANESE HERBAL MEDICINE), SAI-REI-TO, IN MONGOLIAN GERBIL MIDDLE-EAR EPITHELIUM", Japanese Journal of Pharmacology, 73(1), 1997, pp. 29-32

Abstract

Sai-rei-to, a type of Kampo medicine (Japanese herbal medicine), has been shown to be clinically effective in treating patients with otitismedia with effusion. The effect of Sai-rei-to on the ion transport ofthe middle ear surface epithelium cultured from the Mongolian gerbil was investigated by using an Ussing chamber. Application of Sai-rei-toto the mucosal bath but not the serosal bath induced an increase in the short-circuit current (I-SC) in the basal state. The increase in I-SC was almost completely inhibited by addition of diphenylamine-2-carboxylic acid but not by amiloride, indicating enhancement of Cl- secretion. On the basis of the lack of changes in the intracellular Ca2+ concentration and a sideness of action, the effect of Sai-rei-to on Ise is thought to be a direct and selective activation on the apical Cl- channel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/08/20 alle ore 21:51:30