Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
THE HITCHHIKING EFFECT ON THE SITE FREQUENCY-SPECTRUM OF DNA POLYMORPHISMS
Autore:
BRAVERMAN JM; HUDSON RR; KAPLAN NL; LANGLEY CH; STEPHAN W;
Indirizzi:
UNIV CALIF DAVIS,CTR POPULAT BIOL DAVIS CA 95616 UNIV CALIF DAVIS,EVOLUT & ECOL SECT DAVIS CA 95616 UNIV CALIF IRVINE,DEPT ECOL & EVOLUTIONARY BIOL IRVINE CA 92717 NIEHS,STAT & BIOMATH BRANCH RES TRIANGLE PK NC 27709 UNIV MARYLAND,DEPT ZOOL COLLEGE PK MD 20742
Titolo Testata:
Genetics
fascicolo: 2, volume: 140, anno: 1995,
pagine: 783 - 796
SICI:
0016-6731(1995)140:2<783:THEOTS>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
DROSOPHILA-ANANASSAE POPULATIONS; MOLECULAR GENETIC-VARIATION; CENTROMERIC REGION; X-CHROMOSOME; MELANOGASTER; RECOMBINATION; NEUTRALITY; MUTATIONS; SIMULANS; LOCUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Braverman et al., "THE HITCHHIKING EFFECT ON THE SITE FREQUENCY-SPECTRUM OF DNA POLYMORPHISMS", Genetics, 140(2), 1995, pp. 783-796

Abstract

The level of DNA sequence variation is reduced in regions of the Drosophila melanogaster genome where the rate of crossing over per physical distance is also reduced. This observation has been interpreted as support for the simple model of genetic hitchhiking, in which directional selection on rare variants, e.g., newly arising advantageous mutants, sweeps linked neutral alleles to fixation, thus eliminating polymorphisms near the selected site. However, the frequency spectra of segregating sites of several loci from some populations exhibiting reduced levels of nucleotide diversity and reduced numbers of segregating sites did not appear different from what would be expected under a neutralequilibrium model. Specifically, a skew toward an excess of rare sites was not observed in these samples, as measured by Tajima's D. Because this skew was predicted by a simple hitchhiking model, yet it had never been expressed quantitatively and compared directly to DNA polymorphism data, this paper investigates the hitchhiking effect on the sitefrequency spectrum, as measured by Tajima's D and several other statistics, using a computer simulation model based on the coalescent process and recurrent hitchhiking events. The results presented here demonstrate that under the simple hitchhiking model (1) the expected value of Tajima's D is large and negative (indicating a skew toward rare variants), (2) that Tajima's test has reasonable power to detect a skew inthe frequency spectrum for parameters comparable to those from actualdata sets, and (3) that the Tajima's Ds observed in several data setsare very unlikely to have been the result of simple hitchhiking. Consequently, the simple hitchhiking model is not a sufficient explanationfor the DNA polymorphism at those loci exhibiting a decreased number of segregating sites yet not exhibiting a skew in the frequency spectrum.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 18:37:33