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Titolo:
FOLLOW-UP AFTER CURATIVE SURGERY FOR COLORECTAL-CARCINOMA - RANDOMIZED COMPARISON WITH NO FOLLOW-UP
Autore:
OHLSSON B; BRELAND U; EKBERG H; GRAFFNER H; TRANBERG KG;
Indirizzi:
LUND UNIV,DEPT SURG S-22185 LUND SWEDEN LUND UNIV,DEPT SURG S-22185 LUND SWEDEN HELSINGBORG HOSP,DEPT SURG HELSINGBORG SWEDEN
Titolo Testata:
Diseases of the colon & rectum
fascicolo: 6, volume: 38, anno: 1995,
pagine: 619 - 626
SICI:
0012-3706(1995)38:6<619:FACSFC>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARCINOEMBRYONIC ANTIGEN; CANCER; COLON; RESECTION; RECTUM; RECURRENCE; ADENOCARCINOMA; MANAGEMENT; METASTASES; PATTERNS;
Keywords:
COLORECTAL CANCER; FOLLOW-UP; RECURRENCE; SURVIVAL; CARCINOEMBRYONIC ANTIGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
B. Ohlsson et al., "FOLLOW-UP AFTER CURATIVE SURGERY FOR COLORECTAL-CARCINOMA - RANDOMIZED COMPARISON WITH NO FOLLOW-UP", Diseases of the colon & rectum, 38(6), 1995, pp. 619-626

Abstract

PURPOSE: This study investigated the value of intense follow-up compared with no follow-up after curative surgery of cancer in the colon orrectum. METHODS: One hundred seven patients were randomized to no follow-up (control group; n = 54) or intense follow-up (follow-up group; n = 53) after surgery and early postoperative colonoscopy. Patients inthe follow-up group were followed at frequent intervals with clinicalexamination, rigid proctosigmoidoscopy, colonoscopy, computed tomography of the pelvis (in patients operated with abdominoperineal resection), pulmonary x-ray, liver function tests, and determinations of carcinoembryonic antigen and fecal hemoglobin. Follow-up ranged from 5.5 to8.8 years after primary surgery. RESULTS: Tumor recurred in 18 patients (33 percent) in the control group and in 17 patients (32 percent) in the follow-up group. Reresection with curative intent was performed in three patients in the control group and in five patients (four of whom were asymptomatic) in the follow-up group. In the follow-up group two asymptomatic patients with elevated carcinoembryonic antigen levels were disease-free three and five and one-half years after reresection and were the only patients apparently cured by reresection. No patient underwent surgery for metastatic disease in the liver or lungs. Symptomatic metachronous carcinoma was detected in one patient (control group) after three years. Five-year survival rate was 67 percent in thecontrol group and 75 percent in the follow-up group (P > 0.05); the corresponding cancer-specific survival rates were 71 percent and 78 percent, respectively. CONCLUSION: Intense follow-up after resection of colorectal cancer did not prolong survival in this study.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 23:43:02