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Titolo:
PLATELET SEROTONIN-2A RECEPTORS - A POTENTIAL BIOLOGICAL MARKER FOR SUICIDAL-BEHAVIOR
Autore:
PANDEY GN; PANDEY SC; DWIVEDI Y; SHARMA RP; JANICAK PG; DAVIS JM;
Indirizzi:
UNIV ILLINOIS,INST PSYCHIAT,DEPT PSYCHIAT,1601 W TAYLOR ST CHICAGO IL60612
Titolo Testata:
The American journal of psychiatry
fascicolo: 6, volume: 152, anno: 1995,
pagine: 850 - 855
SICI:
0002-953X(1995)152:6<850:PSR-AP>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING-SITES; FRONTAL-CORTEX; PHOSPHOINOSITIDE HYDROLYSIS; AFFECTIVE-DISORDERS; CSF; VICTIMS; 5-HT2; METABOLITES; DEPRESSION; CORTISOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
G.N. Pandey et al., "PLATELET SEROTONIN-2A RECEPTORS - A POTENTIAL BIOLOGICAL MARKER FOR SUICIDAL-BEHAVIOR", The American journal of psychiatry, 152(6), 1995, pp. 850-855

Abstract

Objective: Abnormalities in the serotonergic system have been implicated in suicidal behavior. Higher numbers of serotonin-2 (5-HT2) receptors have been reported in the post-mortem brain of suicide victims. Inorder to further examine the role of 5-HT2A receptors in suicidal behavior, the authors studied 5-HT2A receptors in platelets of suicidal and nonsuicidal patients as well as normal comparison subjects. Method:5-HT2A receptor levels were determined by using [I-125]LSD as a radioligand in platelets obtained from hospitalized psychiatric patients (N=131) and nonhospitalized normal comparison subjects (N=40) during a drug-free baseline period. Patients were diagnosed according to DSM-III-R criteria, and suicidal behavior was identified by using the Hamilton Depression Rating Scale. Results: The mean maximum number of bindingsites (B-max) of platelet 5-HT2A receptors for all suicidal patients rues significantly higher than for nonsuicidal patients or normal comparison subjects. This significant difference remained when subgroups of suicidal patients with depression, schizophrenia,, schizoaffective disorder, or bipolar illness were compared to the other two subject groups. The higher number of platelet 5-HT2A receptors in suicidal patients was independent of diagnosis. While there was no significant difference in B-max between patients with serious suicidal ideation and these who made suicidal attempts, both groups had significantly higher B-max than normal comparison subjects. Conclusions: The observed higher number of platelet 5-HT2A receptors in suicidal patients is independentof diagnosis and appears to be associated with both the brain and theplatelets of suicidal patients. These results thus suggest the potential usefulness of platelet 5-HT2A receptors as a biological marker foridentifying suicide-prone patients.

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Documento generato il 25/11/20 alle ore 19:01:18