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Titolo:
QUANTIFIED MULTIDIMENSIONAL ASSESSMENT OF AUTISM AND OTHER PERVASIVE DEVELOPMENTAL DISORDERS - APPLICATION FOR BIOCLINICAL RESEARCH
Autore:
HAMEURY L; ROUX S; BARTHELEMY C; ADRIEN JL; DESOMBRE H; SAUVAGE D; GARREAU B; LELORD G;
Indirizzi:
CHU BRETONNEAU,DEPT PSYCHOPATHOL ENFANT & NEUROPHYSIOL DEV,2 BD TONNELLE F-37044 TOURS FRANCE
Titolo Testata:
European child & adolescent psychiatry
fascicolo: 2, volume: 4, anno: 1995,
pagine: 123 - 135
SICI:
1018-8827(1995)4:2<123:QMAOAA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
BEHAVIORAL SUMMARIZED EVALUATION; HOMOVANILLIC-ACID; CHILDREN; RELIABILITY; METABOLITES; VALIDITY; SCALE; FLUID;
Keywords:
AUTISTIC DISORDER; PERVASIVE DEVELOPMENTAL DISORDERS; CLUSTER ANALYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
L. Hameury et al., "QUANTIFIED MULTIDIMENSIONAL ASSESSMENT OF AUTISM AND OTHER PERVASIVE DEVELOPMENTAL DISORDERS - APPLICATION FOR BIOCLINICAL RESEARCH", European child & adolescent psychiatry, 4(2), 1995, pp. 123-135

Abstract

A large number of investigation techniques are used to establish the relationships between the clinical and biological data which are necessary for physiopathological analysis in the field of developmental disorders. It therefore seemed necessary to develop a quantified groupingsystem, based on developmental assessments, which could allow closer matching between clinical evaluations and biological numerical data. Two hundred and two subjects presenting developmental disorders (autistic disorder, pervasive developmental disorder not otherwise specified and mental retardation) were examined. For each child, a quantification of autistic behaviour, intellectual impairment, neurological signs and language and communication disorders was performed. A cluster analysis of these quantified data elicited four subgroups according to the scores obtained in these four different areas. We showed the value of this approach by applying it to one of the studies of monoamines routinely examined in childhood autism - dopamine and HVA, its main urinaryderivative. Moreover, this method revealed a subgroup within the total population which was independent of nosographic classification and which had a particular clinical and biochemical profile. Other applications could follow, for example in the fields of neurophysiology, cerebral imaging, molecular biology and genetics.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 01:29:57