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Titolo:
THE DESIGN AND PHYSICAL CHARACTERISTICS OF A SMALL ANIMAL POSITRON EMISSION TOMOGRAPH
Autore:
BLOOMFIELD PM; RAJESWARAN S; SPINKS TJ; HUME SP; MYERS R; ASHWORTH S; CLIFFORD KM; JONES WF; BYARS LG; YOUNG J; ANDREACO M; WILLIAMS CW; LAMMERTSMA AA; JONES T;
Indirizzi:
HAMMERSMITH HOSP,CTR CLIN SCI,MRC,CYCLOTRON UNIT,PET METHODOL GRP,DUCANE RD LONDON ENGLAND CTI,PET SYST KNOXVILLE TN 00000 BYARS CONSULTING OAK RIDGE TN 00000
Titolo Testata:
Physics in medicine and biology
fascicolo: 6, volume: 40, anno: 1995,
pagine: 1105 - 1126
SICI:
0031-9155(1995)40:6<1105:TDAPCO>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-RESOLUTION PET; SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
P.M. Bloomfield et al., "THE DESIGN AND PHYSICAL CHARACTERISTICS OF A SMALL ANIMAL POSITRON EMISSION TOMOGRAPH", Physics in medicine and biology, 40(6), 1995, pp. 1105-1126

Abstract

A small diameter positron emission tomograph, designed specifically for small animal studies, was constructed from existing, commercially available, bismuth germanate (EGO) detectors and electronics. The scanner consists of 16 EGO detector blocks arranged to give a tomograph with a diameter of 115 mm and an axial field of view (FOV) of 50 mm. Eachblock is cut to produce eight (axial) by seven (radial) individual detector elements. The absence of interplane septa enables the acquisition of 3D data sets consisting of 64 sinograms. A 2D, data set of 15 sinograms, consisting of eight direct and seven adjacent cross planes, can be extracted from the 3D data set. Images are reconstructed from the 20 sinograms using a conventional filtered backprojection algorithm. Two methods of normalization were investigated, based on either a rotating Ge-68 rod source, or a uniform Ge-68 plane source, with a uniform cylindrical F-18 phantom. Attenuation of the emitted photons was estimated using a rotating Ge-68 rod source. The transaxial resolution ofthe tomograph was measured as 2.3 mm full width at half maximum (FWHM) and 5.6 mm full width at tenth maximum (FWTM) at the centre of the FOV, degrading to 6.6 mm (radial) and 4.4 mm (tangential) FWHM and 10.4mm (radial) and 14.4 mm (tangential) FWTM at 40.0 mm from the centre of the Fov. The axial slice width was 4.3 mm FWHM, 10.3 mm FWTM at thecentre of the transaxial field of view and 4.4 mm FWHM, 10.6 mm FWTM at 20.0 mm from the centre of the FOV. A scatter fraction of 31.0% wasmeasured at 250-850 keV, for an F-18 line source centred in a 60 mm diameter, water-filled phantom, reducing to 20.4% and 13.8% as the lower energy discrimination was increased to 380 keV and 450 keV, respectively. The count rate performance was measured using a noise equivalentcount rate method, and the linearity of the dead time correction was confirmed over the count rates encountered during routine scanning. In20 mode, the absolute sensitivity of the tomograph was measured as 9948 counts s(-1) MBq(-1) at 250-850 keV, 8284 counts s(-1) MBq(-1) at 380-850 keV and 6280 counts s(-1) MBq(-1) at 450-850 keV.

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Documento generato il 29/11/20 alle ore 15:26:33