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Titolo:
APOPTOSIS - THE IN-VIVO MECHANISM WHICH MEDIATES SPONTANEOUS AK-5 TUMOR-REGRESSION
Autore:
KHAR A; PARDHASARADHI BVV; VARALAKSHMI C; ALI AM; MANOGARAN PS;
Indirizzi:
CTR CELLULAR & MOLEC BIOL HYDERABAD 500007 ANDHRA PRADESH INDIA
Titolo Testata:
Immunology letters
fascicolo: 1-2, volume: 46, anno: 1995,
pagine: 165 - 168
SICI:
0165-2478(1995)46:1-2<165:A-TIMW>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER CELLS; DNA FRAGMENTATION; HISTIOCYTOMA; LYMPHOCYTES; PROTEIN; DEATH;
Keywords:
APOPTOSIS IN VIVO; TUMOR REGRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
A. Khar et al., "APOPTOSIS - THE IN-VIVO MECHANISM WHICH MEDIATES SPONTANEOUS AK-5 TUMOR-REGRESSION", Immunology letters, 46(1-2), 1995, pp. 165-168

Abstract

We have studied the mechanism of induction of apoptosis in a rat histiocytoma in vivo. Tumor cells are killed by necrosis and apoptosis when injected into immune animals; however, naive animals are incapable of killing the tumor cells. Tumor cells show DNA fragmentation within 3h after transplantation in the peritoneal cavity. Natural killer (NK)cells act as the effector in causing tumor cell death through apoptosis since animals depleted of their NK cell population did not show target cell DNA fragmentation. Herbimycin A inhibits the induction of apoptosis, suggesting the requirement for protein phosphorylation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 05:20:14