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Titolo:
INFLUENCE OF BAY K-8644, A CALCIUM-CHANNEL AGONIST, ON THE ANTICONVULSANT ACTIVITY OF CONVENTIONAL ANTI-EPILEPTICS AGAINST ELECTROCONVULSIONS IN MICE
Autore:
GASIOR M; KLEINROK Z; CZUCZWAR SJ;
Indirizzi:
SCH MED,DEPT PHARMACOL & TOXICOL,JACZEWSKIEGO 8 PL-20090 LUBLIN POLAND SCH MED,DEPT PHARMACOL & TOXICOL PL-20090 LUBLIN POLAND
Titolo Testata:
Neuropharmacology
fascicolo: 4, volume: 34, anno: 1995,
pagine: 433 - 438
SICI:
0028-3908(1995)34:4<433:IOBKAC>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIPPOCAMPAL CA1 NEURONS; ANTIEPILEPTIC DRUGS; RAT-BRAIN; FLUNARIZINE; CONVULSIONS; INHIBITORS; NIMODIPINE; PHENYTOIN; EFFICACY; BLOCKERS;
Keywords:
ANTI-EPILEPTICS; CARBAMAZEPINE; DIPHENYLHYDANTOIN; PHENOBARBITAL; VALPROATE; FLUNARIZINE; BAY K-8644; SEIZURES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
M. Gasior et al., "INFLUENCE OF BAY K-8644, A CALCIUM-CHANNEL AGONIST, ON THE ANTICONVULSANT ACTIVITY OF CONVENTIONAL ANTI-EPILEPTICS AGAINST ELECTROCONVULSIONS IN MICE", Neuropharmacology, 34(4), 1995, pp. 433-438

Abstract

BAY k-8644, an agonist at the dihydropyridine binding site of the L-type voltage dependent calcium channel, at the dose of 5 mg/kg (s.c.) did not significantly affect the threshold for electroconvulsions, but impaired the protective efficacy of flunarizine(15 and 20 mg/kg, i.p.)in the electroconvulsive test. Interestingly, the calcium channel agonist (at 1 and 5 mg/kg) distinctly diminished the protection offered by conventional anti-epileptic drugs (carbamazepine, diphenylhydantoin and phenobarbital) against maximal electroshock-induced seizures in mice. A. pharmacokinetic interaction does not seem to be involved in theeffect of BAY k-8644, since total plasma levels of these anti-epileptics (measured by immunofluorescence) were not affected by the calcium channel agonist. The only anti-epileptic drug resistant to BAY k-8644 (up to 5 mg/kg) was valproate, whose ED(50) (in mg/kg) was not changedin the presence of the calcium channel agonist. Further, BAY k-8644 (5 mg/kg) did not influence the flunarizine (a calcium channel blocker)-induced potentiation of the protective action of valproate against maximal electroshock-induced convulsions. The calcium channel agonist (5 mg/kg) reversed the flunarizine-induced augmentation of the anticonvulsive activity of carbamazepine. It may be concluded that carbamazepine, diphenylhydantoin and phenobarbital partially exert their anticonvulsive effects via blockade of calcium influx whilst valproate does not seem to. In this context, the flunarizine-induced potentiation of the anticonvulsive activity of valproate is probably independent of calcium channel blockade.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:06:09