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Titolo:
EVIDENCE FOR CONTINUOUS HAIR CELL REGENER ATION IN A SONG BIRD WITH HEREDITARY COCHLEAR HEARING-LOSS
Autore:
GLEICH O; DOOLING RJ; MANLEY GA; KLUMP GM; STRUTZ J;
Indirizzi:
UNIV REGENSBURG,HNO KLIN,FRANZ JOSEF STR ALLEE 11 D-93042 REGENSBURG GERMANY
Titolo Testata:
HNO. Hals-, Nasen-, Ohrenarzte
fascicolo: 5, volume: 43, anno: 1995,
pagine: 287 - 293
SICI:
0017-6192(1995)43:5<287:EFCHCR>2.0.ZU;2-8
Fonte:
ISI
Lingua:
GER
Keywords:
HAIR CELL REGENERATION; SENSORINEURAL HEARING LOSS; COCHLEAR PATHOLOGY; PAPILLA BASILARIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
O. Gleich et al., "EVIDENCE FOR CONTINUOUS HAIR CELL REGENER ATION IN A SONG BIRD WITH HEREDITARY COCHLEAR HEARING-LOSS", HNO. Hals-, Nasen-, Ohrenarzte, 43(5), 1995, pp. 287-293

Abstract

In recent years evidence has accumulated that birds in contrast to mammals have a great capacity to replace lost hair cells after cochlear trauma. Despite this capacity for cochlear repair, a hereditary hearing deficit for frequencies above 2 kHz has been described in a peculiarstrain of canaries (Belgian Waterslagers). Because previous thresholds were determined by psychophysical methods, the origin of the hearingloss could not be identified. In order to determine if this loss originated in the cochlea and if these birds lack the potential for hair cell regeneration, we carried out physiological and morphological analyses of the hearing organ. Our results showed that most of the hair cells displayed severe pathologies. Also, found were small, microvilli-covered cells that resembled forms described during normal hair cell development. Small microvilli-covered cells with small streov illar bundles have been described as regenerating hair cells in other birds aftersevere cochlear insults. These observations indicate that adult Belgian Waterslager canaries continuously produce new cochlear hair cells. They do not, however, succeed in reforming a normal basilar papilla. We believe that these birds are a promising model for future studies ofcochlear hair cell repair mechanisms.

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Documento generato il 30/11/20 alle ore 02:46:34