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Titolo:
CALCIUM-CHANNEL BLOCKERS AND VITAMIN-E FOR TARDIVE-DYSKINESIA IN ADULTS WITH MENTAL-RETARDATION
Autore:
RICKETTS RW; SINGH NN; ELLIS CR; CHAMBERS S; SINGH YN; CARMANICO SJ; VADNEY V; COOKE JC;
Indirizzi:
VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT PSYCHIAT RICHMOND VA 23298 VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT PSYCHIAT RICHMOND VA 23298 ABILENE PROFESS CTR ABILENE TX 79603 ABILENE STATE SCH ABILENE TX 79604 S DAKOTA STATE UNIV,COLL PHARM,DEPT PHARMACEUT SCI BROOKINGS SD 57006 VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT PEDIAT RICHMOND VA 23298
Titolo Testata:
Journal of developmental and physical disabilities
fascicolo: 2, volume: 7, anno: 1995,
pagine: 161 - 174
SICI:
1056-263X(1995)7:2<161:CBAVFT>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMMUNITY RESIDENTIAL FACILITIES; CEREBROSPINAL-FLUID; NIFEDIPINE; PSYCHOSIS; VERAPAMIL;
Keywords:
TARDIVE DYSKINESIA; CALCIUM CHANNEL BLOCKERS; VERAPAMIL; VITAMIN-E; MENTAL RETARDATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
R.W. Ricketts et al., "CALCIUM-CHANNEL BLOCKERS AND VITAMIN-E FOR TARDIVE-DYSKINESIA IN ADULTS WITH MENTAL-RETARDATION", Journal of developmental and physical disabilities, 7(2), 1995, pp. 161-174

Abstract

Tardive dyskinesia (TD) is one of the major problems associated with the long-term use of neuroleptic medication in individuals with mentalretardation. Although no satisfactory treatment is currently available for TD, there has been a suggestion in the research literature that,in theory, calcium channel blockers and vitamin E may be effective inreducing the symptoms of TD. We assessed the effects of verapamil, a calcium channel blocker, and vitamin E on TD in seven adults with mental retardation in a double-blind, placebo-controlled, cross-over study. Following an open baseline, each subject received placebo, verapamil(80 mg/qid), and vitamin E (400 IU/tid) in random order, with each phase lasting 8 weeks. The subjects were rated on the Abnormal Involuntary Movement Scale (AIMS) and the Dyskinesia Identification System: Condensed User Scale (DISCUS) by trained raters. The maintenance medication for all subjects was kept constant during the course of the study. Results showed that although some subjects had a reduction in their TDratings neither verapamil nor vitamin E produced clinically or statistically significant changes when compared to placebo and baseline conditions. However, the changes associated with vitamin E were promising enough to warrant further investigation of this agent in the treatmentof TD in individuals with mental retardation.

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Documento generato il 25/09/20 alle ore 08:08:07