Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
RELAXATION OF HUMAN TEMPORAL ARTERY BY ENDOTHELIN ET(B) RECEPTORS
Autore:
LUCAS GA; WHITE LR; JUUL R; CAPPELEN J; AASLY J; EDVINSSON L;
Indirizzi:
UNIV TRONDHEIM HOSP,DEPT NEUROL N-7006 TRONDHEIM NORWAY UNIV TRONDHEIM HOSP,DEPT NEUROL N-7006 TRONDHEIM NORWAY UNIV TRONDHEIM HOSP,DEPT NEUROSURG N-7006 TRONDHEIM NORWAY UNIV LUND HOSP,DEPT INTERNAL MED S-22185 LUND SWEDEN
Titolo Testata:
Peptides
fascicolo: 7, volume: 17, anno: 1996,
pagine: 1139 - 1144
SICI:
0196-9781(1996)17:7<1139:ROHTAB>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CONTRACTION; CEREBRAL VASOSPASM; NITRIC-OXIDE; SUBARACHNOID HEMORRHAGE; CHROMOSOMAL ASSIGNMENT; BLOOD-VESSELS; ETB RECEPTOR; ANTAGONIST; POTENT; ET(A);
Keywords:
HUMAN TEMPORAL ARTERY; ENDOTHELIN; ENDOTHELIN RECEPTORS; ENDOTHELIN ANTAGONISTS; FR 139317; BOSENTAN; IRL 1620; INDOMETHACIN; NITRIC OXIDE SYNTHASE INHIBITOR; VASOACTIVE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
G.A. Lucas et al., "RELAXATION OF HUMAN TEMPORAL ARTERY BY ENDOTHELIN ET(B) RECEPTORS", Peptides, 17(7), 1996, pp. 1139-1144

Abstract

Endothelin receptors have been characterized in human temporal arteryby molecular biological methods and in vitro pharmacology. Reverse transcriptase-polymerase chain reaction was used to detect mRNA encodingET(A) and ET(B) receptors in normal and endothelium-denuded arteries. Vasomotor response experiments with a specific ET(A) antagonist (FR 139317) suggested the presence of ET(A) subtypes. Marked ET(B)-mediatedrelaxation was obtained with ET-3 when ET(A) activity was blocked in precontracted arteries. Relaxation was significantly reduced by bosentan, indomethacin, and a nitric oxide synthase inhibitor. It may be speculated that the relaxant activity is mediated through ET(B1) receptors. Copyright (C) 1996 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 17:33:01