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Titolo:
INHIBITORY POTENCY OF ISOPRENALINE ON GUINEA-PIG AND GRAVID HUMAN MYOMETRIUM FOLLOWING EXTRANEURONAL UPTAKE BLOCKADE
Autore:
KOUSIDES M; STORY ME; PENNEFATHER JN; ZICCONE SP; ROSS AW;
Indirizzi:
MONASH UNIV,DEPT PHARMACOL CLAYTON VIC 3168 AUSTRALIA MONASH UNIV,DEPT PHARMACOL CLAYTON VIC 3168 AUSTRALIA ROYAL WOMENS HOSP,DEPT ANAESTHET CARLTON VIC 3053 AUSTRALIA
Titolo Testata:
Reproduction, fertility and development
fascicolo: 1, volume: 7, anno: 1995,
pagine: 59 - 66
SICI:
1031-3613(1995)7:1<59:IPOIOG>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
RABBIT UTERINE ENDOMETRIUM; OVARIAN-STEROIDS; RAT-HEART; NORADRENALINE; METABOLISM; PREGNANCY; UTERUS; PROGESTERONE; LAYERS;
Keywords:
BETA-ADRENOCEPTORS; 3'5'-CYCLIC ADENOSINE MONOPHOSPHATE; INTRACELLULAR BETA-ADRENOCEPTORS; ESTROGEN; PREGNANCY; PROGESTERONE; UTERINE CONTRACTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
M. Kousides et al., "INHIBITORY POTENCY OF ISOPRENALINE ON GUINEA-PIG AND GRAVID HUMAN MYOMETRIUM FOLLOWING EXTRANEURONAL UPTAKE BLOCKADE", Reproduction, fertility and development, 7(1), 1995, pp. 59-66

Abstract

The hypothesis that inhibitory effects of isoprenaline on myometrial contractility may be constrained by activation of putative intracellular beta-adrenoceptors negatively-coupled to adenylate cyclase was examined. Field-stimulated preparations of guinea-pig and human myometriumwere used to examine the influence of the catecholamine extraneuronaluptake(2) inhibitors, corticosterone and beta-oestradiol, on the inhibitory effects of the beta-adrenoceptor agonist, isoprenaline, on uterine contraction. Longitudinal and circular myometrial layers were obtained from guinea-pigs in dioestrus, primed with oestrogen before progesterone, or pregnant (Days 62-65). In the guinea-pig myometrium, corticosterone (30 mu M) did not affect responses to isoprenaline. beta-oestradiol (10 mu M) induced a small potentiation of the effects of isoprenaline on longitudinal myometrium from dioestrous guinea-pigs. Myometrial preparations were obtained from pregnant women (36-40 weeks gestation) undergoing caesarean section. Isoprenaline inhibited stimulation-evoked contractions in 7 of 10 preparations of the inner myometrial layer and in 5 of 8 preparations of outer myometrial layer. Corticosterone (30 mu M) reduced the effects of isoprenaline on the inner layer and did not affect the outer layer. These results do not support the existence of a mechanism involving isoprenaline-sensitive intracellular receptors which constrain responses to beta-adrenoceptor agonists.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/11/20 alle ore 21:40:52