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Titolo:
ENHANCED VIRUS-RESISTANCE OF TRANSGENIC MICE EXPRESSING THE HUMAN MXAPROTEIN
Autore:
PAVLOVIC J; ARZET HA; HEFTI HP; FRESE M; ROST D; ERNST B; KOLB E; STAEHELI P; HALLER O;
Indirizzi:
UNIV FREIBURG,INST MED MICROBIOL & HYG,DEPT VIROL,VIROL ABT,HERMANN HERDER STR 11 D-79008 FREIBURG GERMANY UNIV FREIBURG,INST MED MICROBIOL & HYG,DEPT VIROL,VIROL ABT D-79008 FREIBURG GERMANY
Titolo Testata:
Journal of virology
fascicolo: 7, volume: 69, anno: 1995,
pagine: 4506 - 4510
SICI:
0022-538X(1995)69:7<4506:EVOTME>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFLUENZA-VIRUS; CONSTITUTIVE EXPRESSION; CONFERS RESISTANCE; CELLULAR PROTEINS; INTERFERON; INHIBITION; INFECTION; GAMMA; GENES; GTPASE;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
J. Pavlovic et al., "ENHANCED VIRUS-RESISTANCE OF TRANSGENIC MICE EXPRESSING THE HUMAN MXAPROTEIN", Journal of virology, 69(7), 1995, pp. 4506-4510

Abstract

MxA is a GTPase that accumulates to high levels in the cytoplasm of interferon-treated human cells. Expression of MxA cDNA confers to transfected cell lines a high degree of resistance against several RNA viruses, including influenza, measles, vesicular stomatitis, and Thogoto viruses. We have now generated transgenic mice that express MxA cDNA inthe brain and other organs under the control of a constitutive promoter. Embryonic fibroblasts derived from the transgenic mice were nonpermissive for Thogoto virus and showed reduced susceptibility for influenza A and vesicular stomatitis viruses, The transgenic animals survived challenges with high doses of Thogoto virus by the intracerebral or intraperitoneal route. Furthermore, the transgenic mice were more resistant than their nontransgenic littermates to intracerebral infectionswith influenza A and vesicular stomatitis viruses. These results demonstrate that MxA is a powerful antiviral agent in vivo, indicating that it may protect humans from the deleterious effects of infections with certain viral pathogens.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 03:13:29