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Titolo:
IDENTIFICATION OF A NOVEL HUMAN ZINC-FINGER PROTEIN THAT SPECIFICALLYINTERACTS WITH THE ACTIVATION DOMAIN OF LENTIVIRAL TAT PROTEINS
Autore:
FRIDELL RA; HARDING LS; BOGERD HP; CULLEN BR;
Indirizzi:
DUKE UNIV,MED CTR,HOWARD HUGHES MED INST DURHAM NC 27710 DUKE UNIV,MED CTR,HOWARD HUGHES MED INST DURHAM NC 27710 DUKE UNIV,MED CTR,DEPT GENET DURHAM NC 27710
Titolo Testata:
Virology
fascicolo: 2, volume: 209, anno: 1995,
pagine: 347 - 357
SICI:
0042-6822(1995)209:2<347:IOANHZ>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; HIV-1 TAT; MUTATIONAL ANALYSIS; TRANSCRIPTION FACTOR; FUNCTIONAL-ANALYSIS; BINDING PROTEIN; TRANS-ACTIVATOR; GENE-EXPRESSION; TYPE-1; RNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
67
Recensione:
Indirizzi per estratti:
Citazione:
R.A. Fridell et al., "IDENTIFICATION OF A NOVEL HUMAN ZINC-FINGER PROTEIN THAT SPECIFICALLYINTERACTS WITH THE ACTIVATION DOMAIN OF LENTIVIRAL TAT PROTEINS", Virology, 209(2), 1995, pp. 347-357

Abstract

Transcriptional activation of HIV-1 gene expression by the viral Tat protein requires the interaction of a cellular cofactor with the Tat activation domain. This domain has been shown to consist of the cysteine-rich and core motifs of HIV-1 Tat and is functionally conserved in the distantly related Tat proteins of HIV-2 and EIAV. Using the yeast two-hybrid system, we have identified a novel human gene product, termed HT2A, that specifically and precisely binds to the activation domainof HIV-1 Tat and that can also interact with the HIV-2 and EIAV Tat proteins in vivo. We present data further demonstrating that the interaction between the activation domain of HIV-1 Tat and the HT2A protein can be readily detected in the mammalian cell nucleus. Sequence analysis demonstrates that HT2A is a novel member of the C3HC4 or ring finger family of zinc finger proteins that includes several known oncogenesand transcription factors. Overall, these data suggest that HT2A may play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo. (C) 1995 Academic Press, Inc.

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Documento generato il 27/11/20 alle ore 04:36:27