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Titolo:
PROGNOSTIC-SIGNIFICANCE OF 3 NOVEL BIOLOGIC FACTORS IN A CLINICAL-TRIAL OF ADJUVANT THERAPY FOR NODE-NEGATIVE BREAST-CANCER
Autore:
YAMASHITA J; OGAWA M; SAKAI K;
Indirizzi:
FUKUOKA UNIV,SCH MED,DEPT SURG 2,JOHNAN KU,NANAKUMA 7-45-1 FUKUOKA 81401 JAPAN KUMAMOTO UNIV,SCH MED,DEPT SURG 2 KUMAMOTO 860 JAPAN
Titolo Testata:
Surgery
fascicolo: 6, volume: 117, anno: 1995,
pagine: 601 - 608
SICI:
0039-6060(1995)117:6<601:PO3NBF>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMINOGEN-ACTIVATOR PRODUCTION; IMMUNOREACTIVE ENDOTHELIN-1; GROWTH-FACTOR; TISSUE-TYPE; CELL-LINES; PHOSPHOLIPASE-A2; UROKINASE; FIBROBLASTS; EXPRESSION; RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
J. Yamashita et al., "PROGNOSTIC-SIGNIFICANCE OF 3 NOVEL BIOLOGIC FACTORS IN A CLINICAL-TRIAL OF ADJUVANT THERAPY FOR NODE-NEGATIVE BREAST-CANCER", Surgery, 117(6), 1995, pp. 601-608

Abstract

Background. Five products of human breast carcinoma cells, including membrane-associated phospholipase A(2) (M-PLA(2)), polymorphonuclear leukocyte elastase (PMN-E), tissue-type plasminogen activator (t-PA), urokinase-type plasminogen activator (u-PA), and endothelin-1 (ET-1), have been implicated in the processes of tumor cell invasion and metastasis in human breast carcinoma. However, the prognostic significance of these factors has not been assessed previously in node-negative breast carcinoma, in which adjuvant treatment is dependent on risk stratification. Methods. The five products of breast carcinoma cells were measured in 184 patients with node-negative breast carcinoma who were enrolled in the Kumamoto Adjuvant Chemo-Endocrine Therapy for Breast Cancer prospective randomized trial, and the predictive values of these factors for relapse-free and overall survival were evaluated. Results. M-PLA(2), PMN-E, and t-PA were found to be significant independent predictors of relapse-free and overall survival, whereas u-PA and ET-1 were not independently predictive. Further statistical analyses showed that the predictive powers of M-PLA(2), PMN-E, and t-PA were additive. Acombination of these three factors identified a group of patients (approximately 50% of those who manifested node-negative breast carcinoma) with a favorable prognosis, regardless of the administration of adjuvant therapy. Conclusions. This study identified three biologic factors that are valuable predictors of survival in node-negative breast carcinoma. A combination of these biologic factors may allow identification of low-risk patients who could be spared adjuvant therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 15:49:05