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Titolo:
THE IN-VITRO MOTILITY OF HUMAN GLIOMAS INCREASES WITH INCREASING GRADE OF MALIGNANCY
Autore:
CHICOINE MR; SILBERGELD DL;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT NEUROL SURG,CAMPUS BOX 8057,660 S EUCLIDAVE ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT NEUROL SURG ST LOUIS MO 63110
Titolo Testata:
Cancer
fascicolo: 12, volume: 75, anno: 1995,
pagine: 2904 - 2909
SICI:
0008-543X(1995)75:12<2904:TIMOHG>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMAL GROWTH-FACTOR; CENTRAL-NERVOUS-SYSTEM; GLIOBLASTOMA-MULTIFORME; HUMAN BRAIN; CELLS; INVITRO; ONCOGENES; SURVIVAL; CULTURES; RECEPTOR;
Keywords:
BRAIN TUMOR; CELL CULTURE; CELL MOTILITY; GLIOMA; MALIGNANCY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
M.R. Chicoine e D.L. Silbergeld, "THE IN-VITRO MOTILITY OF HUMAN GLIOMAS INCREASES WITH INCREASING GRADE OF MALIGNANCY", Cancer, 75(12), 1995, pp. 2904-2909

Abstract

Background. Malignant gliomas are a highly invasive disease with a dismal prognosis despite aggressive therapeutic interventions. Methods. The authors tested the hypothesis that increasing in vitro motility ofhuman glial tumors correlates with increasing grade of malignancy. A radial dish assay was used to quantitatively assess the brain tumor cell motility of 14 low passage cell lines derived from human glial tumors of varied malignancy, and 3 cell lines derived from human glia. Theegress of cells from a central region of high tumor cell density to aregion of lower tumor cell density was determined at various time points, A motility coefficient (MC), the slope of distance traveled against time, was generated by simple linear regression analysis. Results. The MC increased with the increased histologic grade of malignancy. Generation of a t-statistic was used to determine the significance of differences in motility among 5 histopathologic groups: 10 glioblastoma (World Health Organization Grade IV) cell lines (mean MC, 0.00396), 2 mixed anaplastic oligoastrocytoma (Grade III) cell lines (mean MC, 0.00382), 1 anaplastic astrocytoma (Grade III) cell line (mean MC, 0.00295), 1 Grade I glioma cell line (mean MC, 0.00206), and 3 human glial cell lines (mean MC, 0.00110). Conclusions. The radial dish assay provided a reproducible method for quantitatively assessing brain tumor cell motility. The higher MC observed with the malignant human glioma cell lines correlated with the tendency of these tumors to invade into adjacent brain tissue. The potential to inhibit glial tumor motility mayprovide an important therapeutic avenue in the future.

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Documento generato il 30/11/20 alle ore 19:02:32