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Titolo:
STRUCTURE-ACTIVITY-RELATIONSHIPS AMONG A NEW CLASS OF ANTIVIRAL HETEROSUBSTITUTED 2',3'-DIDEOXYNUCLEOSIDE ANALOGS
Autore:
MANSOUR TS; JIN H; WANG W; DIXIT DM; EVANS CA; TSE HLA; BELLEAU B; GILLARD JW; HOOKER E; ASHMAN C; CAMMACK N; SALOMON H; BELMONTE AR; WAINBERG MA;
Indirizzi:
BIOCHEM THERAPEUT INC,275 ARMAND FRAPPIER BLVD LAVAL PQ H7V 4A7 CANADA GLAXO GRP RES LTD,RES & DEV,DEPT VIROL GREENFORD UB6 0HE MIDDX ENGLAND JEWISH GEN HOSP,LADY DAVIS INST MED RES MONTREAL PQ H3T 1E2 CANADA MCGILL UNIV,CTR AIDS MONTREAL PQ H3T 1E2 CANADA
Titolo Testata:
Nucleosides & nucleotides
fascicolo: 3-5, volume: 14, anno: 1995,
pagine: 627 - 635
SICI:
0732-8311(1995)14:3-5<627:SAANCO>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATITIS-B VIRUS; DIOXOLANE NUCLEOSIDE ANALOGS; POTENT ANTI-HIV; ASYMMETRIC SYNTHESES; AGENTS; STEREOISOMERS; REPLICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
T.S. Mansour et al., "STRUCTURE-ACTIVITY-RELATIONSHIPS AMONG A NEW CLASS OF ANTIVIRAL HETEROSUBSTITUTED 2',3'-DIDEOXYNUCLEOSIDE ANALOGS", Nucleosides & nucleotides, 14(3-5), 1995, pp. 627-635

Abstract

3'-Oxa-4'-thiocytidine nucleoside analogues 14-17 were prepared from oxathiolanes 10 and 11, and evaluated for activity against HIV-1 and HBV in vitro. The nucleoside analogues were found to possess potent activities against HIV-1 in a panel of cell lines. Compound 16 is moderately active against HBV in 2.2.15 cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 03:46:03