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Titolo:
MYOCARDIAL PERFUSION IMAGING WITH TECHNETIUM-99M-TC NOET - COMPARISONWITH TL-201 AND CORONARY ANGIOGRAPHY
Autore:
FAGRET D; MARIE PY; BRUNOTTE F; GIGANTI M; LEGULUDEC D; BERTRAND A; WOLF JE; PIFFANELLI A; CHOSSAT F; BEKHECHI D; PASQUALINI R; MACHECOURT J; COMET M;
Indirizzi:
FAC MED GRENOBLE,ETUD RADIOPHARMACEUT LAB,CNRS,URA 1287 F-38700 LA TRONCHE FRANCE CHU NANCY BRABOIS,NUCL MED SERV NANCY FRANCE CHU NANCY BRABOIS,SERV CARDIOL NANCY FRANCE CHU DIJON,SERV MED NUCL & CLIN CARDIOL DIJON FRANCE UNIV FERRARA,INST RADIOL I-44100 FERRARA ITALY CHU BICHAT,NUCL MED SERV PARIS FRANCE CHU GRENOBLE,SERV MED NUCL & CLIN NUCL F-38043 GRENOBLE FRANCE
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 6, volume: 36, anno: 1995,
pagine: 936 - 943
SICI:
0161-5505(1995)36:6<936:MPIWTN>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
VIABLE MYOCARDIUM; ARTERY DISEASE; TL-201; REINJECTION;
Keywords:
MYOCARDIAL PERFUSION IMAGING; TC-99M COMPOUNDS; TCN-NOET; TL-201;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
D. Fagret et al., "MYOCARDIAL PERFUSION IMAGING WITH TECHNETIUM-99M-TC NOET - COMPARISONWITH TL-201 AND CORONARY ANGIOGRAPHY", The Journal of nuclear medicine, 36(6), 1995, pp. 936-943

Abstract

We compared TcN-NOET [bis(N-ethoxy, N-ethyl dithiocarbamato)nitrido (TC)-T-99m] and Tl-201 images to estimate the utility of this compound in the detection of coronary artery disease (CAD). Methods: Twenty-five patients undergoing cardiac catheterization had stress-redistribution-reinjection Tl-201 SPECT imaging, stress-delayed (2, 4 and 6 hr postinjection) and rest-delayed (4 hr postinjection) TcN-NOET SPECT imaging. Results: Nineteen patients had coronary stenosis greater than or equal to 50% and six were normal. Stress TcN-NOET and Tl-201 imaging were concordant for the presence of CAD in 22/25 patients (88%, kappa = 0.76 +/- 0.20). The overall sensitivity of TcN-NOET SPECT imaging was 74% (14/19 patients) and 68% (13/19 patients) for Tl-201 SPECT imaging. The specificity was 100% (6/6 patients) for both techniques. The overall agreement of TcN-NOET and Tl-201 for the presence of disease in individual coronary arteries was 96% (72/75 arteries, kappa = 0.92 +/- 0.16). Segmental analysis of stress images showed a concordance in 211/225 segments (94%, kappa = 0.82 +/- 0.09). Comparison of the 4-hr images showed a concordance between Tl-201 and TcN-NOET in 21/23 patients. Following TcN-NOET injection at rest, seven patients had a defect on the initial images, which had normalized 4 hr postinjection in four patients (57%). Conclusion: Perfusion imaging with TcN-NOET and Tl-201 gives comparable diagnostic information in patients undergoing exercisetesting for assessment of CAD. Because of the normalization of myocardial activity 4 hr after injection in some patients, we conclude that TcN-NOET is a potential technetium compound equivalent to Tl-201.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 17:19:50