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Titolo:
PERFUSION CHANGES IN THE RIF-1 TUMOR AND NORMAL-TISSUES AFTER CARBOGEN AND NICOTINAMIDE, INDIVIDUALLY AND COMBINED
Autore:
HONESS DJ; BLEEHEN NM;
Indirizzi:
MRC CTR,MRC UNIT,HILLS RD CAMBRIDGE CB2 2QH ENGLAND UNIV CAMBRIDGE,MRC CTR,DEPT CLIN ONCOL & RADIOTHERAPEUT CAMBRIDGE CB22QH ENGLAND
Titolo Testata:
British Journal of Cancer
fascicolo: 6, volume: 71, anno: 1995,
pagine: 1175 - 1180
SICI:
0007-0920(1995)71:6<1175:PCITRT>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOUSE MAMMARY-CARCINOMA; RADIATION-THERAPY; NORMOBARIC OXYGEN; RADIOSENSITIZATION; PHARMACOKINETICS; INVIVO; CELLS; MICE; RADIOTHERAPY; ENHANCEMENT;
Keywords:
CARBOGEN BREATHING; NICOTINAMIDE; RELATIVE TISSUE PERFUSION; RIF-1 TUMOR; NORMAL TISSUES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
D.J. Honess e N.M. Bleehen, "PERFUSION CHANGES IN THE RIF-1 TUMOR AND NORMAL-TISSUES AFTER CARBOGEN AND NICOTINAMIDE, INDIVIDUALLY AND COMBINED", British Journal of Cancer, 71(6), 1995, pp. 1175-1180

Abstract

The strategy of combining carbogen breathing and nicotinamide to overcome chronic and acute hypoxia respectively is being evaluated clinically. The effects of both agents individually and in combination on relative perfusion of 400-700 mm(3) RIF-1 tumours and normal tissues weremeasured by Rb-86 extraction. Carbogen breathing alone for 6 min increased relative tumour perfusion by 50-70% compared with control at Bowrates of 50 to 200 ml min(-1), but the effect was lost at 300 ml min(-1). All flow rates also produced similar increases in relative perfusion of lung, of between 36% and 58%, and smaller increases in skin, ofbetween 20% and 34%. The minimum breathing time at 150 ml min(-1) to produce a significant increase in relative tumour perfusion was 4.5 min, and the effect was maintained up to 9 min. Nicotinamide alone at 1000 mg kg(-1) 60 min before assay did not alter relative tumour perfusion. Comparing the combination of nicotinamide with 6 min carbogen breathing at 150 ml min(-1) with carbogen breathing alone showed no difference in relative tumour perfusion; increases were of 36% and 42% respectively. Nicotinamide-induced alterations in microcirculation associated with reduction of acute hypoxia have therefore not been detected byRb-86 extraction. The perfusion-enhancing effect of carbogen in this tumour is probably an important component of its radiosensitising ability, in addition to its known ability to increase the oxygen-carrying capacity of the blood, and should be taken into consideration in clinical studies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 13:32:29