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Titolo:
STAGE SPECIFICITY OF ARA-C INDUCED CARPAL AND TARSAL BONE ANOMALIES IN MICE
Autore:
RAHMAN ME; ISHIKAWA H; WATANABE Y; ENDO A;
Indirizzi:
YAMAGATA UNIV,SCH MED,DEPT HYG & PREVENT MED YAMAGATA 99023 JAPAN YAMAGATA UNIV,SCH MED,DEPT HYG & PREVENT MED YAMAGATA 99023 JAPAN YAMAGATA UNIV,SCH MED,DEPT ORTHOPED SURG YAMAGATA 99023 JAPAN
Titolo Testata:
Reproductive toxicology
fascicolo: 3, volume: 9, anno: 1995,
pagine: 289 - 296
SICI:
0890-6238(1995)9:3<289:SSOAIC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOSINE-ARABINOSIDE; MOUSE EMBRYOS; SKELETON; MATINGS; PERIOD; RAT;
Keywords:
CRITICAL PERIOD; CARPAL AND TARSAL BONE ANOMALIES; DIGIT ANOMALIES; ARA-C; MICE; POSTNATAL ANALYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
M.E. Rahman et al., "STAGE SPECIFICITY OF ARA-C INDUCED CARPAL AND TARSAL BONE ANOMALIES IN MICE", Reproductive toxicology, 9(3), 1995, pp. 289-296

Abstract

Pregnant mice were injected intraperitoneally with a single dose of 5mg/kg of cytosine arabinoside (Ara-C) on different gestational days (dg 9-12). On the 15th postnatal day, skeletal anomalies of the paws were examined, and associations between carpal and tarsal bone anomaliesand digit anomalies were assessed. The types of carpal and tarsal bone anomalies differed according to the time of exposure to Ara-C duringpregnancy. It was also found that the ''critical period'' for the carpal and tarsal bones is wider than that of the digits. The occurrence of anomalies of phalangeal and metacarpal/metatarsa1 bones was always associated with carpal or tarsal bone anomalies, although some carpal and tarsal bone anomalies occurred alone. It may be that the Ara-C threshold is considerably lower in the carpal and tarsal bones than in the digits.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 18:39:27