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Titolo:
OCTREOTIDE BLUNTS POSTPRANDIAL SPLANCHNIC HYPEREMIA IN CIRRHOTIC-PATIENTS - A DOUBLE-BLIND RANDOMIZED ECHO-DOPPLER STUDY
Autore:
BUONAMICO P; SABBA C; GARCIATSAO G; BERARDI E; ANTONICA G; FERRAIOLI G; JENSEN JE; LERNER E; TAYLOR KJW; ALBANO O; GROSZMANN RJ;
Indirizzi:
YALE UNIV,VET ADM MED CTR,HEPAT HEMODYNAM LAB,950 CAMPBELL AVE,111H WHAVEN CT 06516 YALE UNIV,VET ADM MED CTR,HEPAT HEMODYNAM LAB W HAVEN CT 06516 UNIV BARI,IST CLIN MED 1 BARI ITALY YALE UNIV,SCH MED,DEPT DIAGNOST RADIOL NEW HAVEN CT 00000 OSPED CIVILI SCAFATI,DIV MED SALERNO ITALY VET ADM MED CTR,RES SERV W HAVEN CT 00000
Titolo Testata:
Hepatology
fascicolo: 1, volume: 21, anno: 1995,
pagine: 134 - 139
SICI:
0270-9139(1995)21:1<134:OBPSHI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
PORTAL BLOOD-FLOW; SOMATOSTATIN ANALOG; SMS 201-995; PANCREATIC-SECRETION; CONSCIOUS DOG; ULTRASOUND; HORMONES; RELEASE; HUMANS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
P. Buonamico et al., "OCTREOTIDE BLUNTS POSTPRANDIAL SPLANCHNIC HYPEREMIA IN CIRRHOTIC-PATIENTS - A DOUBLE-BLIND RANDOMIZED ECHO-DOPPLER STUDY", Hepatology, 21(1), 1995, pp. 134-139

Abstract

The effect of octreotide, a long-acting synthetic analog of somatostatin, on fasting and postprandial splanchnic hemodynamics was investigated in cirrhotic patients, Splanchnic hemodynamics were assessed usingan echo-Doppler duplex system in a prospective, double-blind, placebo-controlled, crossover study performed on 2 separate days, 1 week apart, in 30 cirrhotic patients. Measurements of portal vein (PV) cross-sectional area (PV-A) and mean velocity (PV-V), and of superior mesenteric artery (SMA) mean velocity (SMA-V) and pulsatility index (SMA-PI) (an index of vascular resistance) were performed at baseline, 30 minutes after octreotide (200 mu g subcutaneously) or placebo administration, and 30 and 60 minutes after the ingestion of a liquid meal. In the fasted state, octreotide induced a significant decrease in PV-V (-7%) and in SMA-V (-10%) and an increase in PI (+16%). On the day of placeboadministration, meal ingestion induced a significant increase in PV-V(+21%) and in SMA-V (+43%) and a decrease in PI (-21%). In contrast, meal ingestion on octreotide day induced significantly smaller increases in PV-V (+10%) and in SMA-V (+18%) and a significantly smaller decrease in PI (-10%). Octreotide, although producing a mild reduction in PV-V and SMA-V in the fasted state, markedly blunts postprandial splanchnic hyperemia in cirrhotic patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/08/20 alle ore 09:04:49