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Titolo:
EFFECT OF CORTICOSTEROID-BINDING GLOBULIN ON THE PHARMACOKINETICS OF PREDNISOLONE IN RATS
Autore:
KO HC; ALMON RR; JUSKO WJ;
Indirizzi:
SUNY BUFFALO,SCH PHARM,DEPT PHARMACEUT,565 HOCHSTETTER HALL BUFFALO NY 14260 SUNY BUFFALO,SCH PHARM,DEPT PHARMACEUT BUFFALO NY 14260 SUNY BUFFALO,DEPT BIOL SCI BUFFALO NY 14260
Titolo Testata:
Pharmaceutical research
fascicolo: 6, volume: 12, anno: 1995,
pagine: 902 - 904
SICI:
0724-8741(1995)12:6<902:EOCGOT>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CIRCULATING CORTICOSTERONE; PROTEIN BINDING; INFANT RATS; PHARMACODYNAMICS; MODEL; METHYLPREDNISOLONE; DISPOSITION; ELIMINATION; INVIVO; SERUM;
Keywords:
CORTICOSTEROID BINDING GLOBULIN; TRANSCORTIN; PHARMACOKINETICS; FREE HORMONE HYPOTHESIS; PREDNISOLONE; METHYLPREDNISOLONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
H.C. Ko et al., "EFFECT OF CORTICOSTEROID-BINDING GLOBULIN ON THE PHARMACOKINETICS OF PREDNISOLONE IN RATS", Pharmaceutical research, 12(6), 1995, pp. 902-904

Abstract

Purpose. The effect of exogenous corticosteroid binding globulin (CBG) on the pharmacokinetics of intravenous prednisolone was determined in rats to test the ''free hormone hypothesis. '' Methods. A dose of CBGto yield 95% binding with 1000 ng/ml of prednisolone in vitro in rat plasma or saline was administered before dosing 2 mg/kg of prednisolone hemisuccinate or methylprednisolone intravenously. Drug concentrations in plasma samples were assayed by HPLC. Results. Single administration of CBG decreased apparent prednisolone clearance by 56% (155 to 66ml/min/kg) and reduced apparent V-SS by 35% (4.1 to 2.7 L/kg) (p<0.001). Methylprednisolone pharmacokinetics, studied as a negative controlbecause the drag does not bind to CBG, did not change. Conclusions. The corticosteroid bound to CBG does not appear to be available for removal by clearance organs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 16:07:17