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Titolo:
PLACENTAL FETAL HORMONAL INTERACTIONS - IMPACT ON FETAL GROWTH
Autore:
ANTHONY RV; PRATT SL; LIANG R; HOLLAND MD;
Indirizzi:
COLORADO STATE UNIV,DEPT PHYSIOL,ANIM REPROD & BIOTECHNOL LAB FT COLLINS CO 80523
Titolo Testata:
Journal of animal science
fascicolo: 6, volume: 73, anno: 1995,
pagine: 1861 - 1871
SICI:
0021-8812(1995)73:6<1861:PFHI-I>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPLEMENTARY DEOXYRIBONUCLEIC-ACID; PROLACTIN-LIKE PROTEIN; MESSENGER-RIBONUCLEIC-ACID; DEVELOPING RAT PLACENTA; FACTOR-II GENE; MOLECULAR-CLONING; BOVINE PLACENTA; CDNA CLONE; CHORIONIC SOMATOMAMMOTROPIN; LATE-GESTATION;
Keywords:
FETUS; PLACENTA; PLACENTAL HORMONES; IGF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
113
Recensione:
Indirizzi per estratti:
Citazione:
R.V. Anthony et al., "PLACENTAL FETAL HORMONAL INTERACTIONS - IMPACT ON FETAL GROWTH", Journal of animal science, 73(6), 1995, pp. 1861-1871

Abstract

The placenta plays a critical role in providing an environment that supports optimal fetal growth. It does this by providing the site of nutrient transfer from the mother to the fetus and waste secretion from the fetus to the mother, acting as a barrier against pathogens and thematernal immune system, and as an active endocrine organ capable of secreting hormones, growth factors, cytokines, and other bioactive products. Among the hormones produced by the placenta are members of the growth hormone/prolactin gene family, the placental lactogens (PL) and prolactin-related proteins. Although the exact functions of the placental members of this gene family have not been entirely elucidated, theavailable evidence supports a role for some in modulating maternal and fetal metabolism. The-FL are secreted into the maternal and fetal circulations and, at least in ruminants, seem to mediate their effects through unique receptors, although this remains controversial. One action of the PL may be to modulate fetal IGF production. Research with mice, using gene ablation techniques, indicates the importance of the IGF for maintaining normal fetal growth rate. This research provided data on the timing of the onset of IGF effects on fetal growth and the receptors through which these effects are mediated. This review is aboutthe structure, mechanism of action, and potential function of the placental members of the growth hormone/prolactin gene family and the recent evidence on the role of IGF in fetal growth regulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 16:40:18