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Titolo:
EFFECTS OF CONDITIONED FEAR STRESS ON 5-HT RELEASE IN THE RAT PREFRONTAL CORTEX
Autore:
YOSHIOKA M; MATSUMOTO M; TOGASHI H; SAITO H;
Indirizzi:
HOKKAIDO UNIV,SCH MED,DEPT PHARMACOL 1,KITA KU,KITA-15,NISHI-7 SAPPORO HOKKAIDO 060 JAPAN
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 2-3, volume: 51, anno: 1995,
pagine: 515 - 519
SICI:
0091-3057(1995)51:2-3<515:EOCFSO>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN TRYPTOPHAN; GUINEA-PIG; SEROTONIN; METABOLISM; RECEPTORS; BEHAVIOR; BENZODIAZEPINES; IMMOBILIZATION; NORADRENALINE; ACTIVATION;
Keywords:
SEROTONIN; CONDITIONED FEAR STRESS; FOOT SHOCK; FREEZING BEHAVIOR; MEDIAL PREFRONTAL CORTEX; IN VIVO MICRODIALYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
M. Yoshioka et al., "EFFECTS OF CONDITIONED FEAR STRESS ON 5-HT RELEASE IN THE RAT PREFRONTAL CORTEX", Pharmacology, biochemistry and behavior, 51(2-3), 1995, pp. 515-519

Abstract

The effects of conditioned fear stress (CFS) on 5-HT release in the medial prefrontal cortex were studied by in vivo microdialysis. CFS (exposure to an environment in which foot-shock had been delivered previously) induced a marked suppression of motility-that is, freezing behavior. The extracellular concentration of 5-HT in the medial prefrontal cortex increased during this freezing behavior, but no significant changes were observed in the concentration of its metabolite, 5-HIAA. Theincreased 5-HT concentration returned to pretreatment levels when theanimals were returned to their home cages. Diazepam (0.5 mg/kg, intraperitoneally) reduced the CFS-induced freezing behavior and prevented the increases in extracellular 5-HT levels. A 5-HT3 receptor antagonist, tropisetron (10 and 100 mu g/kg), also inhibited both the CFS-induced increase in 5-HT release and the freezing behavior. These findings suggest that there is a relationship between anxiety and 5-HT release in the prefrontal cortex and that the 5-HT3 receptor antagonist tropisetron might have anxiolytic properties.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 12:57:22