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Titolo:
EFFECTS OF SERTINDOLE ON SLEEP-WAKE STATES, ELECTROENCEPHALOGRAM, BEHAVIORAL-PATTERNS, AND EPILEPTIC ACTIVITY OF RATS
Autore:
COENEN AML; ATES N; SKARSFELDT T; VANLUIJTELAAR ELJM;
Indirizzi:
UNIV NIJMEGEN,DEPT PSYCHOL,NICI,POB 9104 6500 HE NIJMEGEN NETHERLANDS H LUNDBECK & CO AS,PHARMACOL RES COPENHAGEN DENMARK
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 2-3, volume: 51, anno: 1995,
pagine: 353 - 357
SICI:
0091-3057(1995)51:2-3<353:EOSOSS>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
SLOW-WAVE SLEEP; POSTSYNAPTIC ACTION; ABSENCE EPILEPSY; 5-HT2 RECEPTORS; EEG; RITANSERIN; WAKEFULNESS; MODELS; DRUGS; CLASSIFICATION;
Keywords:
SERTINDOLE; 5-HT2 ANTAGONIST; SLEEP-WAKE STATES; BEHAVIOR; EEG SPECTRAL ANALYSIS; SPIKE-WAVE DISCHARGES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
A.M.L. Coenen et al., "EFFECTS OF SERTINDOLE ON SLEEP-WAKE STATES, ELECTROENCEPHALOGRAM, BEHAVIORAL-PATTERNS, AND EPILEPTIC ACTIVITY OF RATS", Pharmacology, biochemistry and behavior, 51(2-3), 1995, pp. 353-357

Abstract

In this study we addressed the effects of the 5-HT2 receptor antagonist sertindole in rats. The compound was administered in doses of 0.08,0.32, and 1.28 mg/kg, whereas a control group received the solvent. The effects of sertindole on sleep-wake states, behavioral patterns, and background electroencephalogram were studied. Following injection ofdrug or solvent, we recorded the electroencephalogram and electromyogram for two periods of 4 h in the dark period of the light-dark cycle on 2 successive days. On the Ist day sertindole induced a significant increase in deep slow-wave sleep, but only with a dose of 0.32 mg/kg. Furthermore, a decrease in REM sleep in all three drug groups was established. The suppression of REM sleep was still present on the 2nd day. Sertindole also induced a decrease in alternation between behavioralpatterns on the Ist day. There were no significant changes in the spectral content of the background electroencephalogram. In a parallel experiment it appeared that sertindole had no main effects on epileptic spike-wave discharges. This was established with a dose of 1.28 mg/kg sertindole in rats with absence seizures. These findings suggest that sertindole, similar to other compounds modulating 5-HT2 receptors, influences sleep-wake states in rats by decreasing REM sleep and mildly increasing deep slow-wave sleep, whereas behavioral variation is slightly diminished, with no effects on the background EEG and almost no effects on spike-wave discharges.

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Documento generato il 24/09/20 alle ore 05:26:30