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Titolo:
INVOLVEMENT OF N-METHYL-D-ASPARTATE (NMDA) RECEPTORS IN NONCOMPETITIVE NMDA RECEPTOR ANTAGONIST-INDUCED HYPERLOCOMOTION IN MICE
Autore:
IRIFUNE M; SHIMIZU T; NOMOTO M; FUKUDA T;
Indirizzi:
KAGOSHIMA UNIV,FAC MED,DEPT PHARMACOL KAGOSHIMA 890 JAPAN KAGOSHIMA UNIV,FAC MED,DEPT PHARMACOL KAGOSHIMA 890 JAPAN
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 2-3, volume: 51, anno: 1995,
pagine: 291 - 296
SICI:
0091-3057(1995)51:2-3<291:ION(RI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHENCYCLIDINE-LIKE DRUGS; ACID-INDUCED LETHALITY; NUCLEUS-ACCUMBENS; MK-801; DOPAMINE; ANTICONVULSANT; NOREPINEPHRINE; CONVULSIONS; RELEASE; COMPLEX;
Keywords:
LOCOMOTOR ACTIVITY; N-METHYL-D-ASPARTATE RECEPTOR; DOPAMINE RECEPTOR; MK-801; PHENCYCLIDINE; KETAMINE; HALOPERIDOL; MOUSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
M. Irifune et al., "INVOLVEMENT OF N-METHYL-D-ASPARTATE (NMDA) RECEPTORS IN NONCOMPETITIVE NMDA RECEPTOR ANTAGONIST-INDUCED HYPERLOCOMOTION IN MICE", Pharmacology, biochemistry and behavior, 51(2-3), 1995, pp. 291-296

Abstract

The role of the N-methyl-D-aspartate (NMDA) receptors in hyperlocomotion induced by 11-dihydro-5H-dibenzo[a,d]cyclohydrogen-5,10-imine hydrogen maleate (MK-801), a potent and selective noncompetitive NMDA receptor antagonist, was examined in male ddY mice. A low dose of MK-801 [0.2 mg/kg, intraperitoneally (IP)] produced a marked increase in locomotor activity without obvious staggering gait. In contrast, a high dose (1 mg/kg, IP) induced a typical motor syndrome characterized by increased locomotor activity, stereotyped behavior, and severe ataxia. NMDA (60-120 mg/kg, IP), an NMDA receptor agonist, dose dependently antagonized hyperlocomotion induced by a low dose of MK-801 (0.2 mg/kg). However, even a high convulsive dose of NMDA (240 mg/kg, IP) could not completely antagonize the hyperactivity induced by MK-801. On the otherhand, neither a high dose of N-methyl-L-aspartate (400 mg/ kg, IP), astereoisomer of NMDA, nor a critical subconvulsive dose of kainate (10 mg/kg, IP), a non-NMDA receptor agonist, reversed MK-801-induced hyperlocomotion. The activity induced by MK-801 was potently suppressed by low doses of haloperidol (0.05-0.1 mg/kg, IP), a dopamine (DA) receptor antagonist, in a dose-dependent manner. These data for MK-801 weresimilar to those for phencyclidine and ketamine, other noncompetitiveNMDA receptor antagonists. These results suggest that noncompetitive NMDA receptor antagonist-induced hyperlocomotion is mediated, at leastin part, by NMDA receptor antagonism, although this hyperactivity mayalso involve dopaminergic mechanisms through indirect (perhaps by reducing NMDA receptor-mediated neurotransmission) and/or direct (by inhibiting DA uptake) effects on DA neurons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 03:21:34