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Titolo:
A STUDY OF THE N-METHYL-D-ASPARTATE ANTAGONISTIC PROPERTIES OF ANTICHOLINERGIC DRUGS
Autore:
MCDONOUGH JH; SHIH TM;
Indirizzi:
USA,MED RES INST CHEM DEF,BIOCHEM PHARMACOL BRANCH,MCMR UV PA ABERDEEN PROVING GROUND MD 21010
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 2-3, volume: 51, anno: 1995,
pagine: 249 - 253
SICI:
0091-3057(1995)51:2-3<249:ASOTNA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOMAN-INDUCED SEIZURES; PHENCYCLIDINE-LIKE DRUGS; INDUCED LETHALITY; RAT; ACETYLCHOLINE; CONVULSIONS; HIPPOCAMPUS; INVOLVEMENT; DIAZEPAM; AGENTS;
Keywords:
MOUSE; N-METHYL-D-ASPARTATE; LETHALITY; ANTICHOLINERGIC DRUG; N-METHYL-D-ASPARTATE ANTAGONISTS; ANTI-PARKINSONIAN DRUGS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
J.H. Mcdonough e T.M. Shih, "A STUDY OF THE N-METHYL-D-ASPARTATE ANTAGONISTIC PROPERTIES OF ANTICHOLINERGIC DRUGS", Pharmacology, biochemistry and behavior, 51(2-3), 1995, pp. 249-253

Abstract

Drugs that act at the N-methyl-D-aspartate (NMDA) receptor complex have the ability to terminate nerve agent-induced seizures and modulate the neuropathologic consequences of agent exposure. Drugs with mixed anticholinergic and anti-NMDA properties potentially provide an ideal class of compounds for development as anticonvulsant treatments for nerve agent casualties. The present experiment evaluated the potential NMDA antagonist activity of 11 anticholinergic drugs by determining whether pretreatment with the compound was capable of protecting mice fromthe lethal effects of NMDA. The following anticholinergic drugs antagonized NMDA lethality and are ranked according to their potency: mecamylamine > procyclidine = benactyzine > biperiden > trihexyphenidyl. The anticholinergics atropine, aprophen, azaprophen, benztropine, 3-quinuclidinyl benzilate (QNB), and scopolamine failed to show NMDA antagonist properties. In addition, and unexpectedly, diazepam, ethanol, and pentobarbital were also shown to be capable of antagonizing NMDA lethality over a certain range of doses. The advantages and limitations of using antagonism of NMDA lethality in mice as a bioassay for determining the NMDA antagonist properties of drugs are also discussed.

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Documento generato il 30/11/20 alle ore 03:10:54