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Titolo:
LOWERING OF BODY-TEMPERATURE AFFECTS HUMAN PLATELET FUNCTIONS AND NOREPINEPHRINE RELEASE
Autore:
OPPER C; HENNIG J; CLEMENT C; LASCHEFSKI U; DEY D; DIECKWISCH J; NETTER P; WESEMANN W;
Indirizzi:
UNIV MARBURG,INST PHYSIOL CHEM,HANS MEERWEIN STR D-35033 MARBURG GERMANY UNIV MARBURG,INST PHYSIOL CHEM D-35033 MARBURG GERMANY UNIV GIESSEN,DEPT PSYCHOL D-35385 GIESSEN GERMANY
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 2-3, volume: 51, anno: 1995,
pagine: 217 - 221
SICI:
0091-3057(1995)51:2-3<217:LOBAHP>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; HUMAN-BLOOD PLATELETS; PLASMA-CATECHOLAMINES; CORE TEMPERATURE; STRESS; ATHEROSCLEROSIS; ACTIVATION; COLD; PATHOGENESIS; ENVIRONMENT;
Keywords:
PLATELET FUNCTION; MEAN PLATELET VOLUME; EPINEPHRINE; NOREPINEPHRINE; COLD EXPOSURE; BODY CORE TEMPERATURE; PLATELET DENSITY DISTRIBUTION; IPSAPIRONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
C. Opper et al., "LOWERING OF BODY-TEMPERATURE AFFECTS HUMAN PLATELET FUNCTIONS AND NOREPINEPHRINE RELEASE", Pharmacology, biochemistry and behavior, 51(2-3), 1995, pp. 217-221

Abstract

The effect of lowering body temperature on plasma epinephrine, norepinephrine, and platelet density distribution and volume was studied in a placebo-controlled double-blind study. Lowering of body core temperature was induced by either exposure to a cold environment at a temperature of 5 degrees C (CT) or by a single dose of the 5-HT1A agonist ipsapirone (IPS). A third group exposed to an ambient temperature of 28 degrees C was given placebo (PLAC). All of the three groups were investigated in a climate chamber. In the CT group the density distribution of blood platelet subpopulations was shifted to an increase in less dense platelets that were more sensitive towards aggregation-inducing agents. The mean platelet volume in this subpopulation was decreased. Epinephrine was not affected, whereas the increase of norepinephrine wascorrelated with an increase of platelets that were more sensitive to aggregation-inducing agents in the CT group but not in the PLAC and IPS groups.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 20:54:42