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Titolo:
EARLIER APPEARANCE OF IMPAIRED INSULIN-SECRETION THAN OF VISCERAL ADIPOSITY IN THE PATHOGENESIS OF NIDDM - 5-YEAR FOLLOW-UP OF INITIALLY NONDIABETIC JAPANESE-AMERICAN MEN
Autore:
CHEN KW; BOYKO EJ; BERGSTROM RW; LEONETTI DL; NEWELLMORRIS L; WAHL PW; FUJIMOTO WY;
Indirizzi:
UNIV WASHINGTON,SCH MED,DEPT MED,RG-26 SEATTLE WA 98195 UNIV WASHINGTON,SCH MED,DEPT MED SEATTLE WA 98195 UNIV WASHINGTON,DEPT ANTHROPOL SEATTLE WA 98195 UNIV WASHINGTON,DEPT BIOSTAT SEATTLE WA 98195
Titolo Testata:
Diabetes care
fascicolo: 6, volume: 18, anno: 1995,
pagine: 747 - 753
SICI:
0149-5992(1995)18:6<747:EAOIIT>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT DIABETES-MELLITUS; GLUCOSE-TOLERANCE; FAT DISTRIBUTION; ORAL GLUCOSE; RISK-FACTORS; C-PEPTIDE; RESISTANCE; OBESITY; ASSOCIATION; PREVALENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
K.W. Chen et al., "EARLIER APPEARANCE OF IMPAIRED INSULIN-SECRETION THAN OF VISCERAL ADIPOSITY IN THE PATHOGENESIS OF NIDDM - 5-YEAR FOLLOW-UP OF INITIALLY NONDIABETIC JAPANESE-AMERICAN MEN", Diabetes care, 18(6), 1995, pp. 747-753

Abstract

OBJECTIVE - To identify risk factors for development of non-insulin-dependent diabetes mellitus (NIDDM) during a 5-year longitudinal follow-up of second-generation Japanese-American (Nisei) men. RESEARCH DESIGN AND METHODS - For 5 years, 137 initially nondiabetic Nisei men were followed with 75-g oral glucose tolerance tests at the initial visit and at 2.5- and 5-year follow-up visits. Body fat distribution was assessed by computed tomography (CT) and body mass index (BMI) calculated at each visit. Fasting insulin and C-peptide, the increment of insulinand C-peptide at 30 min after the oral glucose load, intra-abdominal and total subcutaneous fat by CT, and BMI were compared between those who remained nondiabetic (non-DM) and those who had developed NIDDM at2.5 years (DM-A) and 5 years (DM-B). RESULTS - At baseline, the DM-A group had significantly increased intra-abdominal fat, elevated lasting plasma C-peptide, and lower C-peptide response at 30 min after oral glucose. At the 2.5-year follow-up, this group had markedly increased fasting plasma insulin and decreased 30-min insulin and C-peptide response to oral glucose. The DM-B group also had significantly lower insulin response at 30 min alter oral glucose at baseline but no significant difference in intra-abdominal fat or lasting plasma insulin and C-peptide levels. When this group developed NIDDM by 5-year follow-up, however, an increase of intra-abdominal fat was found superimposed on the pre-existing lower insulin response. Fasting plasma insulin and C-peptide remained low. CONCLUSION - In DM-A, lower 30-min insulin response to oral glucose (an indicator of beta-cell lesion) and increased intra-abdominal fat and lasting C-peptide (indicators of insulin resistance) were the risk factors related to the development of NIDDM. DM-B subjects had a lower 30-min insulin response to oral glucose at baselineand increased intra-abdominal fat at 5 years, when they were found tohave NIDDM. Thus, both insulin resistance and impaired beta-cell function contribute to the development of NIDDM in Japanese-Americans, andimpaired beta-cell function may be present earlier than visceral adiposity in some who subsequently develop NIDDM.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 10:39:17