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Titolo:
RELATIVE ANDROGENICITY, BLOOD-PRESSURE LEVELS, AND CARDIOVASCULAR RISK-FACTORS IN YOUNG HEALTHY WOMEN
Autore:
MANTZOROS CS; GEORGIADIS EI; YOUNG R; EVAGELOPOULOU C; KHOURY S; KATSILAMBROS N; SOWERS JR;
Indirizzi:
WAYNE STATE UNIV,SCH MED,DIV ENDOCRINOL HYPERTENS & METAB,UNIV HLTH CTR 4H,4201 ST ANTOINE DETROIT MI 48201 WAYNE STATE UNIV,SCH MED,DIV ENDOCRINOL HYPERTENS & METAB DETROIT MI 48201
Titolo Testata:
American journal of hypertension
fascicolo: 6, volume: 8, anno: 1995,
pagine: 606 - 614
SICI:
0895-7061(1995)8:6<606:RABLAC>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Keywords:
ANDROGENS; BLOOD PRESSURE; CARDIOVASCULAR RISK FACTORS; WOMEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
C.S. Mantzoros et al., "RELATIVE ANDROGENICITY, BLOOD-PRESSURE LEVELS, AND CARDIOVASCULAR RISK-FACTORS IN YOUNG HEALTHY WOMEN", American journal of hypertension, 8(6), 1995, pp. 606-614

Abstract

To test the hypothesis that androgens may play a role in the pathogenesis of atherosclerosis and hypertension, we investigated the association of Delta 5 dehydroepiandrosterone sulfate [DHEAS]) and Delta 4 (free testosterone [FT]) androgens with the resting, seated blood pressure (BP) levels and cardiovascular risk factors in 280 young, healthy women 18 to 24 years of age. After application of multiple regression analysis, systolic BP was positively and independently correlated with the ratio of dehydroepiandrosterone sulfate to free testosterone (DHEAS/FT), fasting insulin levels, and the diastolic BP with DHEAS/FT only. The DHEAS/FT ratio proved to be a stronger predictor of the BP levelsthan either hormone alone. Further, uric acid concentrations and HDL/total cholesterol ratio were independently correlated with both FT andbody mass index in these young women. Serum triglycerides were independently correlated with ET and central body fat distribution. These data suggest that serum androgen concentrations are important independent predictors of cardiovascular risk factors and that the ratio of dehydroepiandrosterone sulfate to free testosterone ratio is an independent predictor of blood pressure levels in young women.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 22:04:40