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Titolo:
RELATION OF P53 TUMOR-SUPPRESSOR PROTEIN EXPRESSION TO HUMAN PAPILLOMAVIRUS (HPV) DNA AND TO CELLULAR ATYPIA IN MALE GENITAL WARTS AND IN PREMALIGNANT LESIONS
Autore:
RANKI A; LASSUS J; NIEMI KM;
Indirizzi:
UNIV OULU,DEPT DERMATOL & VENEREAL DIS,KAJAANINTIE 50 SF-90220 OULU FINLAND TAMPERE UNIV,DEPT DERMATOL & VENEREAL DIS SF-33101 TAMPERE FINLAND HELSINKI UNIV,DEPT DERMATOL & VENEREAL DIS HELSINKI FINLAND
Titolo Testata:
Acta dermato-venereologica
fascicolo: 3, volume: 75, anno: 1995,
pagine: 180 - 186
SICI:
0001-5555(1995)75:3<180:ROPTPE>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
WILD-TYPE; ACTIVATING MUTATIONS; CERVICAL CARCINOMAS; GENE-PRODUCT; E6 PROTEINS; CANCER; FORMS; TRANSCRIPTION; ASSOCIATION; CONDYLOMATA;
Keywords:
BOWENOID PAPULOSIS; IMMUNOHISTOCHEMISTRY; GROWTH REGULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
A. Ranki et al., "RELATION OF P53 TUMOR-SUPPRESSOR PROTEIN EXPRESSION TO HUMAN PAPILLOMAVIRUS (HPV) DNA AND TO CELLULAR ATYPIA IN MALE GENITAL WARTS AND IN PREMALIGNANT LESIONS", Acta dermato-venereologica, 75(3), 1995, pp. 180-186

Abstract

Functional disturbance of p53 tumor suppressor protein contributes touncontrolled cell growth, Human papillomavirus (HPV) E6 oncoproteins bind to wild-type p53 and abrogate its function, Our objective was to elucidate the relation of aberrant p53 protein expression to HPV DNA and cellular atypia in male genital warts and premalignant lesions, Immunohistochemically detectable p53 protein expression was studied in 35male anogenital warts with low-level or no keratinocyte atypia (histologically confirmed condylomata acuminata), in 25 lesions with bowenoid papulosis (BP; carcinoma in situ) histology, and in 10 non-condylomalesions using immunostaining with three established antibodies recognizing full-length wild-type accumulated p53 protein, or its conformational mutants, HPV DNA specific for HPV 6/11, 16/18, or 31/33/35 was identified by in situ hybridization or by polymerase chain reaction (PCR) - based amplification, Both nuclear and cytoplasmic keratinocyte immunostaining for p53 protein was detected in 41% of condylomata with nokeratinocyte atypia and in 42% of condylomata with slight nuclear atypia or with bowenoid papulosis histology, No association of aberrant p53 expression with any specific HPV type or with HPV DNA was observed,Normal skin and some other penile dermatoses were negative for p53 immunostaining. In the follow-up biopsies of 16 BP patients, treated with CO2 laser, recurrence of atypia was seen exclusively in lesions initially positive for both HPV DNA and p53 protein. Our results show thata few cells in male genital warts even with no cellular atypia may express abnormally sequestered or loss-of-function p53 protein, and thatconcomitant presence of any type of HPV DNA is associated with recurrencies or progression of premalignant changes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 04:13:13