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Titolo:
IN-VIVO AUTORADIOGRAPHY OF RADIOIODINATED (R)-3-QUINUCLIDINYL (S)-4-IODOBENZILATE [(R,S)-IQNB] AND (R)-3-QUINUCLIDINYL (R)-4-IODOBENZILATE [(R,R)-IQNB] - COMPARISON OF THE RADIOLABELED PRODUCTS OF A NOVEL TRIBUTYLSTANNYL PRECURSOR WITH THOSE OF THE ESTABLISHED TRIAZENE AND EXCHANGE METHODS
Autore:
SOOD VK; LEE KS; BOULAY SF; RAYEQ MR; MCREE RC; COHEN EI; ZEEBERG BR; HE XS; WEINBERGER DR; RICE K; REBA RC;
Indirizzi:
GEORGE WASHINGTON UNIV,MED CTR,DEPT RADIOL,SECT RADIOPHARMACEUT CHEM,2300 EYE ST NW WASHINGTON DC 20037 GEORGE WASHINGTON UNIV,MED CTR,DEPT RADIOL,SECT RADIOPHARMACEUT CHEM WASHINGTON DC 20037 ST ELIZABETH HOSP,NIMH,CLIN BRAIN DISORDERS BRANCH WASHINGTON DC 20032 UNIV CHICAGO HOSP,DEPT RADIOL,NUCL MED SECT CHICAGO IL 60637 NIDDK,LAB MED,NIH BETHESDA MD 20892
Titolo Testata:
Applied radiation and isotopes
fascicolo: 1, volume: 48, anno: 1997,
pagine: 27 - 35
SICI:
0969-8043(1997)48:1<27:IAOR((>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUSCARINIC ACETYLCHOLINE-RECEPTORS; RAT-BRAIN; ALZHEIMERS-DISEASE; POTENTIAL RADIOPHARMACEUTICALS; INVIVO; SELECTIVITY; TOMOGRAPHY; INVITRO; SUBTYPE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
V.K. Sood et al., "IN-VIVO AUTORADIOGRAPHY OF RADIOIODINATED (R)-3-QUINUCLIDINYL (S)-4-IODOBENZILATE [(R,S)-IQNB] AND (R)-3-QUINUCLIDINYL (R)-4-IODOBENZILATE [(R,R)-IQNB] - COMPARISON OF THE RADIOLABELED PRODUCTS OF A NOVEL TRIBUTYLSTANNYL PRECURSOR WITH THOSE OF THE ESTABLISHED TRIAZENE AND EXCHANGE METHODS", Applied radiation and isotopes, 48(1), 1997, pp. 27-35

Abstract

Radioiodinated (R,S)-IQNB and (R,R)-IQNB are prepared either from a triazene precursor or using an exchange reaction. In both cases the radiochemical yield is low. The product of the exchange reaction also suffers from having a fairly low specific activity. A new method for preparing radioiodinated (R,S)-IQNB and (R,R)-IQNB from a tributylstannyl precursor has recently been developed. This method is more convenient and much faster than the triazene and exchange methods, and it reliably results in a high radiochemical yield of a high specific activity product. In rat brain, the in vivo properties of the radioiodinated products of the tributylstannyl method are identical to those of the corresponding radioiodinated (R,S)-IQNB and (R,R)-IQNB prepared using the triazene and exchange methods. Dissection studies of selected brain regions show that at 3 h post injection (R,S)-[I-125]IQNB prepared by allthree methods have indistinguishable %dose g(-1) values in all brain regions studied. Autoradiographic comparison of coronal slices throughthe anteroventral nucleus of the thalamus, through the hippocampus and through the pens at 2 h post injection shows that (R,S)-[I-125]IQNB prepared by the triazene and tributylstannyl methods have indistinguishable patterns of binding. Copyright (C) 1997 Elsevier Science Ltd

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Documento generato il 27/11/20 alle ore 06:51:02